Abstract
Introduction: In the dental implant and osseointegration scenario, the treatment of oral rehabilitation with implants obtained a substantial evolution. At the time when the concept of osseointegration was pioneered by Branemark, the primary focus was directed toward functional rehabilitation. Objective: The present study aimed to carry out a systematic review of the main considerations of dental implants in osseointegration, as well as to emphasize all the processes involved. Methods: The rules of the Systematic Review-PRISMA Platform were followed. The research was carried out in June to July 2026 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 152 articles were found. A total of 72 articles were fully evaluated and 22 were included in the systematic review. A total of 44 studies were excluded because they did not meet the GRADE and AMSTAR-2 criteria, and 6 studies were excluded because they had a high risk of bias. It was concluded that to maintain osseointegration and prevent bone loss from implants, a better understanding of the osteoimmunology of the peri-implant environment would lead to the development of new therapeutic approaches. It is necessary to discuss immunomodulatory strategies to improve and preserve a long-term functional integration between dental implants and the human body. It is concluded that the bone saucerization around osseointegrated implants represents one of those specific concepts that are part of the implant dentist jargon.