MedNEXT Journal of Medical and Health Sciences https://mednext.zotarellifilhoscientificworks.com/index.php/mednext <div class="row"> <div class="col-lg-2 journal-front"> <div class="journal-front-section-title-left"> </div> <img src="https://mednext.zotarellifilhoscientificworks.com/public/journals/1/journalThumbnail_en_US.jpg" alt="" width="150" height="211" /></div> <div class="col-lg-7 journal-front"> <div class="journal-front-section-title-left">Aim &amp; Scope</div> <p><strong>MedNEXT Journal of Medical and Health Sciences</strong> is a quarterly free open access, peer-reviewed international online journal (E ISSN: 2763-5678) which publishes articles and video articles (optional) in the subjects related to medicine including, clinical trials, aetiology, cardiology, chiropody, cytology, dentistry, dietetics, embryology, ENT, epidemiology, genetics, geriatrics, gerontology, gynecology, hematology, immunology, neurology, obstetrics, oncology, orthopedics, pediatrics, pathology, pharmacy and pharmacology, radiology, surgery, toxicology, rheumatology, urology, virology, ophthalmology, otolaryngology.</p> <p>Moreover, alternative medicine, nursing and allied health sciences, veterinary science, teaching/education methods in medical sciences and artificial intelligence in medicine and health sciences are also welcome. Other interdisciplinary perspectives to integrate the field of medical and health sciences are also encouraged.</p> <p>The journal publishes four issues per year. All the accepted articles will be indexed in Google Scholar and Crossref. A unique DOI number and a Cross mark will also be given to the articles.</p> </div> <div class="col-lg-3 journal-front"> <div class="journal-front-section-title">Journal Description</div> <div class="front-lef"> <p>Title: <strong> MedNEXT Journal of Medical and Health Sciences</strong> <br />E-ISSN: <strong><a title="2763-5678" href="https://portal.issn.org/resource/ISSN/2763-5678" target="_blank" rel="noopener">2763-5678</a></strong><br />Journal Abbreviation: <strong>MedNEXT J Med Health Sci</strong><br />Publication language: <strong>English</strong> <br />Publishing frequency: <strong>Quarterly (February, May, August, November)</strong><br />DOI Prefix: <strong><a title="10.54448" href="https://api.crossref.org/prefixes/10.54448/works" target="_blank" rel="noopener">10.54448</a></strong></p> </div> <div class="jor-sub-but"><strong> <a title="Web of Science Citations " href="https://mjl.clarivate.com/search-results" target="_blank" rel="noopener">Web of Science Citations</a> <br 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Transfer of copyright:</strong></p> <p>The corresponding author or designee below, with the consent of all co-authors, hereby transfers to the publishers and copyright ownership in the referenced submitted work, including all versions in any format now known or hereafter developed and sell the articles worldwide in all languages and media (<u>Publishing Agreement &amp; Copyright Transfer Form</u>).</p> <p><strong>2. Rights and obligations of Publisher:</strong></p> <p>The Publisher’s rights to the Article shall especially include, but shall not be limited to:</p> <ul> <li>Ability to publish an electronic version of the Article via the website of the publisher or any other electronic format or means of electronic distribution provided by or through publisher from time to time, selling the Article world-wide (through subscriptions, Pay-per-View, single archive sale, etc.)</li> <li>Transforming to and selling the Article through any electronic format</li> <li>Publishing the Article in the printed Journals as listed on the official Website of Publisher</li> <li>Transferring the copyright and the right of use of the Article on to any third party</li> <li>Translating the Article in any language</li> <li>Taking measures on behalf of the Author against in fringement, in appropriate use of the Article, libel or plagiarism.</li> </ul> <p>Publishers agrees to send the text of the manuscript to the corresponding author e-mail address of Author indicated in the present Statement for preview before the first publishing either in paper and/or electronic format (Proof). Author should return the corrected test of the manuscript within 5 days to the publisher. Author shall, however, not make any change to the content of the Article during the First Proof preview.</p> <p><strong>3. Rights and obligations of Author:</strong></p> <p>The Author declares and warrants that he/she is the exclusive author of the Article– or has the right to represent all co-authors of the Article and has not granted any exclusive or non-exclusive right to the Article to any third party prior to the execution of the present Statement and has the right therefore to enter in to the present Statement and entitle the Publisher the use of the Article subject to the present Statement. By executing the present Statement Author confirms that the Article is free of plagiarism, and that Author has exercised reasonable care to ensure that it is accurate and, to the best of Author’s knowledge, does not contain any thing which is libellous, or obscene, or infringes on anyone’s copyright, right of privacy, or other rights. The Author expressively acknowledges and accepts that he/she shall been titled to no royalty (or any other fee) related to any use of the Article subject to the present Statement. The Author further accepts that he/she will not been titled to dispose of the copyright of the final, published version of the Article or make use of this version of the Article in any manner after the execution of the present Statement. The Author is entitled, however, to self-archive the preprint version of his/her manuscript. 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Should Author wish to reuse material sourced from third parties such as other copyright holders, publishers, authors, etc. as part of the Article, Author bears responsibility for acquiring and clearing of the third party permissions for such use before submitting the Article to the Publisher for acceptance. Author shall hold Publisher harmless from all third party claims in connection to the unauthorized use of any material under legal protection forming a part of the Article.</p> <p><strong>5.Share with Colleagues:</strong></p> <p>Subject to the publishers, Authors may send or otherwise transmit electronic files of the Submitted or Accepted Work to interested colleagues prior to, or after, publication. Sharing of the Published Work with colleagues is permitted if it is done via the journal articles on Request author-directed link. The sharing of any version of the Work with colleagues is only permitted if it is done for non-commercial purposes; that no fee is charged; and that it is not done on a systematic basis, e.g. mass emailings, posting on a listserv, etc. Recipients should be informed that further redistribution of any version of the Work is not allowed. Authorized users of the publisher’s website may also email a link to the Author’s article directly to colleagues as well as <strong>recommend</strong> and share a link to the Author’s article with known colleagues through popular social networking services such as Facebook, Twitter, or CiteULike.</p> <p><strong>6. Retained Rights:</strong></p> <p>The Author(s) retain copyright and all other intellectual property rights.</p> <p><strong>Article Processing Fees</strong></p> <p>MedNEXT Journal of Medical and Health Sciences is an open access journal. Articles in the journal are free to access, download, share, and re-use. Also, we do not charge any submission charges from the authors. <br /><br /></p> <p><strong>Open Access Statement</strong></p> <p>Creative Commons Licenses<br />MedNEXT Journal of Medical and Health Sciences articles are published open access under a <a href="http://creativecommons.org/licenses/by/4.0/"><em>CC BY license</em></a> (Creative Commons Attribution 4.0 International License). The CC BY license allows for maximum dissemination and re-use of open access materials and is preferred by many research funding bodies. Under this license users are free to share (copy, distribute and transmit) and remix (adapt) the contribution including for commercial purposes, providing they attribute the contribution in the manner specified by the author or licensor (<a href="http://creativecommons.org/licenses/by/4.0/legalcode"><em>read full legal code</em></a>).<br />Under Creative Commons, authors retain copyright in their articles.</p> Major clinical outcomes of melatonin regulation in obesity: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/256 <p><strong>Introduction:</strong> In the scenario of non-communicable chronic diseases, obesity has briefly impacted the global population, causing serious public health problems. There are approximately 2.0 billion overweight and obese people in the world. Brazil ranks fifth in the world with approximately 18.0 million people. Research has advanced on the physiological role of melatonin (MEL) as a therapeutic agent for the treatment of obesity. <strong>Objective:</strong> It was to highlight the main clinical outcomes of melatonin regulation in obesity through a systematic review of the literature. <strong>Methods:</strong> The present study followed a concise systematic review model, following the systematic review rules (PRISMA). The literary search process was carried out from September to October 2022 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar. The low quality of evidence was attributed to case reports, editorials, and brief communications, according to the GRADE instrument. The risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> It was founded 139 studies were submitted to the eligibility analysis, then, 46 of the 54 total studies were selected for this systematic review. According to the GRADE instrument, most studies showed homogeneity in their results, with I2 =98.4% &gt;50%. Studies have shown an important role for melatonin in metabolic diseases such as obesity, type 2 diabetes mellitus, and metabolic syndrome. It is possible to define some pathological syndromes related to MEL and discuss general guidelines for clinical therapy. However, there is still no consensus on the possible role of melatonin as an adjuvant in the treatment of metabolic diseases. More studies are needed to define the possible risks and benefits of melatonin as a therapeutic agent. Furthermore, several precautions must be taken into account, such as restricting the administration of chronic melatonin to the night, carefully choosing the time of administration according to the desired effect, and adapting the dosage and formulation individually to build a melatonin blood profile that mimics the physiological and ends early in the morning.</p> Darwin dos Santos Ribeiro Copyright (c) 2023 Darwin dos Santos Ribeiro https://creativecommons.org/licenses/by/4.0 2023-01-27 2023-01-27 4 1 10.54448/mdnt23101 Main considerations of the temporomandibular joint, its disorders, and treatments: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/255 <p align="justify"><strong>Introduction:</strong> The temporomandibular joint (TMJ) can be affected by end-stage pathologies such as arthritic disease, trauma, and ankylosis. The main debilitating symptoms result in limited mouth opening and pain. The TMJ prosthesis is indicated for diseases that result in anatomical changes and aims to restore joint function with pain relief. Prosthetic replacement for terminal TMJ disease is gradually becoming a common procedure due to good functional results and low morbidity. <strong>Objective:</strong> A concise systematic review was carried out to present the main considerations about the temporomandibular joint, as well as the main clinical results of the treatment of temporomandibular disorders (TMD). <strong>Methods:</strong> The systematic review rules of the PRISMA Platform were followed. The search was carried out from October to December 2022 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, using articles from 2013 to 2022. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 240 articles were found, 65 articles were evaluated in full and 26 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 45 studies with a high risk of bias and 94 studies that did not meet GRADE. It was concluded that the etiology of temporomandibular disorder is multifactorial, with muscle disorders, joint disorders, and muscle disorders affecting mastication muscles. As a treatment, each CAD/CAM component is manufactured using the patient's data. This system is designed for the specific patient situation and should provide a perfect fit. However, the communication of the fossa and condyle articular surfaces of the implant are standardized, as in the stock system. The treatment of TMD is diverse and depends on the type of disease, as well as the duration and subjective level of pain. Alloplastic reconstruction can be advantageous in obtaining a rapid improvement in symptoms and rapid rehabilitation of masticatory function.</p> Thays Souza Freitas Laura Fernanda Andrade Rafaela Rodrigues dos Santos Elias Naim Kassis Copyright (c) 2023 Thays Souza Freitas, Laura Fernanda Andrade, Rafaela Rodrigues dos Santos, Elias Naim Kassis https://creativecommons.org/licenses/by/4.0 2023-01-26 2023-01-26 4 1 10.54448/mdnt23s106 Immune system and epigenomics under the light of spirituality/religiosity https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/254 <p>Introduction: In the scenario of spirituality, immunity, and health, psychological science is considering spirituality/ religiosity (S/R) as a legitimate issue in understanding the human experience, as it can reduce pro-inflammatory cytokines, aberrant DNA methylation, and strengthen immunity. Objective: It was to evaluate the results of clinical studies that addressed the influence of spirituality/ religiosity on the human immune system, gene expression, and health in general. Methods: The systematic review rules of the PRISMA Platform were followed. The search was carried out from October to December 2022 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, using articles from 2005 to 2022. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed accordingly. according to the Cochrane instrument. Results and Conclusion: A total of 120 articles were found, 55 articles were evaluated in full and 31 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 15 studies with a high risk of bias and 32 studies that did not meet GRADE. Results and Conclusion: Spirituality/religiosity plays an important role in epigenomic modulations, given that altered gene transcription and aberrant DNA methylation were observed in the CNS and peripheral T lymphocytes. Church attendance is associated with less herpesvirus reactivation, as indicated by lower levels of CMV IgG antibody titers. Furthermore, better self-reported health was associated with better functioning of the immune system. Spirituality can be considered a good coping strategy used by health professionals to promote mental health, well-being, and strengthening immunity during the COVID-19 pandemic.</p> Dayse Silva Caldeira Copyright (c) 2023 Dayse Silva Caldeira https://creativecommons.org/licenses/by/4.0 2023-01-26 2023-01-26 4 1 10.54448/mdnt23S105 Major aspects of the use of bisphosphonates for dental implants in patients with or without osteoporosis: https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/253 <p>Introduction: In the setting of Medication-Related Osteonecrosis of the Jaw (MRONJ) it was first reported in association with the use of bisphosphonates (BP) by maxillofacial surgeons. The potency and route of administration of BPs are identified as important risk factors. Objective: It was to evaluate the use of bisphosphonates and their side effects in patients with or without osteoporosis, with emphasis on osteonecrosis of the jaws, for dental implants. Methods: The systematic review rules of the PRISMA Platform were followed. The search was carried out from October to December 2022 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, using articles from 2005 to 2022. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed accordingly. according to the Cochrane instrument. Results and Conclusion: A total of 120 articles were found, and 55 articles were evaluated in full and 34 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 15 studies with a high risk of bias and 32 studies that did not meet GRADE. For patients with established osteoporosis, there are drugs that, in general, act directly on the bone remodeling process, seeking to reduce bone resorption, including BP, which are drugs of proven efficacy that act in the prevention and treatment of several bone diseases. Osteoporosis is a factor that delays the regeneration of the maxillary bone in patients submitted to implant surgery, prolonging the normal recovery time of the maxillary bone, which can vary from three to six months. Alendronate sodium is used to decrease bone resorption, the drug should be considered an adjuvant therapeutic agent for the treatment of osteoporosis. However, studies have shown that there is a risk of osteonecrosis with the use of bisphosphonates.</p> Filipe Antônio Munhoz Fabio Alarcon Idalgo Silvio Antonio dos Santos Pereira Alexandre Gomes Nunes Elias Naim Kassis Alvaro José Cicareli Copyright (c) 2023 Filipe Antônio Munhoz, Fabio Alarcon Idalgo, Silvio Antonio dos Santos Pereira, Alexandre Gomes Nunes, Elias Naim Kassis, Alvaro José Cicareli https://creativecommons.org/licenses/by/4.0 2023-01-20 2023-01-20 4 1 10.54448/mdnt23S14 Major clinical results of orthognathic surgery and maxillomandibular advancement in obstructive sleep apnea syndrome https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/249 <p>Introduction: Obstructive sleep apnea involves obstruction or narrowing of an individual's airway during sleep and is associated with several comorbidities. Management can be surgical or nonsurgical, and Phase II of the Stanford Protocol for surgical management involves maxillomandibular advancement. Objective: It was to carry out a concise systematic review to present the main considerations and clinical results of orthognathic surgery in obstructive sleep apnea syndrome. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from September to November 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 270 articles were found, 47 articles were evaluated and 23 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 35 studies at high risk of bias and 125 studies that did not meet the GRADE. Most studies showed homogeneity in their results, with I2 =95.9% &gt;50%. Maxillomandibular advancement surgery is a successful treatment for obstructive sleep apnea, but there are still concerns about the aesthetic results due to the great advances involved. The bimaxillary advancement osteotomy significantly increases the oropharyngeal volume and constricted surface areas, which remains stable between 6 months to 1 year postoperatively.</p> Talysson Silva de Oliveira Morais Gabriela Xavier Lima da Silva Abner da Rocha Cardoso Costa Fabio Alarcon Idalgo Silvio Antonio dos Santos Pereira Alexandre Gomes Nunes Elias Naim Kassis Alvaro José Cicareli Copyright (c) 2023 https://creativecommons.org/licenses/by/4.0 2023-01-12 2023-01-12 4 1 10.54448/mdnt23S103 Use of fat graft to correct facial asymmetries in patients undergoing Orthognathic Surgery: the systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/246 <p><strong>Introduction:</strong> Orthognathic Surgery (OS) aims to correct deformities of the bones of the maxilla and mandible. In this scenario, fat grafting is a powerful tool for corrections and also for facial aesthetic improvement together or after OS. The benefits of fat grafting during orthognathic surgery; to maximize aesthetic results, minimize swelling and optimize wound healing. <strong>Objective:</strong> To analyze the main clinical studies on the benefits and risks of facial fat grafting in orthognathic surgery, to know the current state of the art. <strong>Methods:</strong> It followed a systematic literature review model on the main clinical findings of orthognathic surgery and fat grafting, according to the rules of PRISMA. The research was carried out from January 2021 to May 2021 and developed based on Google Scholar, Scopus, PubMed, Ovid, Scielo, and Cochrane Library. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results:</strong> 123 studies were analyzed, with only 52 medium and high-quality studies selected, according to GRADE rules, and with risks of bias that do not compromise scientific development, based on the Cochrane instrument. Studies have shown that OS aims to establish harmonious facial esthetics, excellent functional occlusion, and improved airway conditions. As an important adjunct to OS, fat grafting is becoming more and more common due to its anti-inflammatory role and effects on facial swelling. High patient satisfaction with the results. Postoperative swelling resolved at week 12 in the fat graft group and persistent edema. The edema decrease over time, with almost complete resolution within 1 year, improvement in facial morphology, function, quality, and skin texture in most of their patients. The use of assisted lipo transfers containing mesenchymal stem cells derived from adipose tissue, enables improvement in skin quality, smoothing of wrinkles, pore size, and attenuation of pigmentation and resolution of scars. Furthermore, enrichment of the lipoaspirate with stem cells derived from adipose tissue increases graft retention. <strong>Conclusion:</strong> Most of the studies analyzed in this review study showed that fat grafting in orthognathic surgery is a safe and effective tool to improve wound healing, improve aesthetic results, present an anti-inflammatory effect and reduce edema.</p> Priscilla Janaína de Lima Borelli Bovo Marcelo Henrique Batista Santos Henrique Esteves Magalhães Luciano Rodrigues Neves Elias Naim Kassis Igor Mariotto Beneti Copyright (c) 2023 Priscilla Janaína de Lima Borelli Bovo, Marcelo Henrique Batista Santos, Henrique Esteves Magalhães, Luciano Rodrigues Neves, Elias Naim Kassis, Igor Mariotto Beneti https://creativecommons.org/licenses/by/4.0 2023-01-05 2023-01-05 4 1 10.54448/mdnt23S102 Major clinical outcomes of cellular and molecular regulation in maxillofacial bone regeneration: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/245 <p><strong>Introduction:</strong> The importance of knowing the constitution of this epithelium is because these hair cells play a fundamental role in the physiology of the maxillary sinus. When a dental element is lost in the posterior region of the maxilla, there is natural reabsorption of the alveolar process and, at the same time, pneumatization of the maxillary sinus will occur. <strong>Objective:</strong> It was to demonstrate, through a systematic review, the main clinical outcomes of cellular and molecular regulation in maxillofacial bone regeneration. <strong>Methods:</strong> The systematic review rules of the PRISMA Platform were followed. The research was carried out from September to October 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. A total of 110 articles were found, 41 articles were evaluated and 31 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 31 studies at high risk of bias and 25 studies that did not meet the GRADE. Most studies showed homogeneity in their results, with I2 =98.9% &gt;50%. <strong>Results and Conclusion:</strong> It was found that the search for a solution to large bone defects guided the studies for regeneration therapy tissue or bone regeneration. These studies can promote the use of fillers and epithelial barriers that help in the treatment as an adjuvant to bone graft techniques, favoring greater predictability in alveolar and peri-implant reconstructions and with a good prognosis. The main filler biomaterials can be fibrin-rich plasma (FRP), Bio-Oss®. It is necessary to understand the chemical, physical and biological processes of both the biological material and the biological niche of the host. Crossing compatible information between microenvironments allows cell recognition and signaling cascades for neovascularization and regeneration and bone filling.</p> Bruna Maria Vital dos Anjos Leandro Gotardello Alves Fabio Alarcon Idalgo Silvio Antonio dos Santos Pereira Alexandre Gomes Nunes Elias Naim Kassis Alvaro José Cicareli Igor Mariotto Beneti Copyright (c) 2023 Bruna Maria Vital dos Anjos, Leandro Gotardello Alves, Fabio Alarcon Idalgo, Silvio Antonio dos Santos Pereira, Alexandre Gomes Nunes, Elias Naim Kassis, Alvaro José Cicareli, Igor Mariotto Beneti https://creativecommons.org/licenses/by/4.0 2023-01-02 2023-01-02 4 1 10.54448/mdnt23S101 Major clinical approaches to osseointegrated implants: a concise systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/244 <p><strong>Introduction:</strong> Reconstructive surgery is an important component of the specialty of oral and maxillofacial surgery. The maxillofacial skeleton is subject to various types of defects secondary to trauma, craniofacial/congenital deformities, and tumor ablation. The complex anatomy and function of the maxillomandibular complex impact the choice of reconstruction for maxillofacial defects. <strong>Objective:</strong> It was to carry out a concise systematic review to present the main considerations of osseointegrated implants. <strong>Methods:</strong> The systematic review rules of the PRISMA Platform were followed. The research was carried out from September to November 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 127 articles were found, and 57 articles were evaluated and 30 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 10 studies with a high risk of bias and 28 studies that did not meet GRADE. Most studies showed homogeneity in their results, with I2 =95.8% &gt;50%. It was concluded that orofacial defects affect both the form and function of the most prominent and complex part of the body, the face. Several options, such as vascularized flaps, non-vascularized autogenous grafts, or allogeneic materials, are available to reconstruct maxillofacial defects. The complex anatomy and function of the maxillomandibular complex impact the choice of reconstruction for maxillofacial defects. The real effect of bisphosphonates on osseointegration and survival of dental implants is still not well established.</p> Adryan de Carvalho Elias Naim Kassis Copyright (c) 2022 Adryan de Carvalho, Elias Naim Kassis https://creativecommons.org/licenses/by/4.0 2022-12-26 2022-12-26 4 1 10.54448/mdnt22S614 Successful orthodontic and surgical treatment of a patient with Class III malocclusion: a clinical case report https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/243 <p><strong>Introduction:</strong> Class III malocclusion affects between 5% and 15% of the entire Brazilian population. <strong>Objective:</strong> The present study aimed to present a clinical case report of the ortho-surgical treatment of a patient with class III malocclusion, showing the follow-up of the good evolution of the treatment and the improvement of the patient's quality of life. <strong>Case Report:</strong> The patient EOMO, male and 53 years old, presented class III and on 02/03/2003 the patient submitted the orthodontic documentation. The first phase was the surgical expansion of the maxilla, orthodontic treatment of alignment, and maxillomandibular leveling. The second phase was maxillary advancement and mandible reduction surgery. On 07/31/2003, EOMO decided to undergo orthodontics and the indicated surgeries. Today, after years of treatment and surgeries, EOMO lives well and his appearance has improved 100%, and today he lives with a good quality of life. <strong>Final considerations:</strong> According to the clinical case presented, the treatment of Class III must be fundamentally based on the diagnosis so that the treatment is installed to correct the compromised structures instead of being compensated in places not affected by this malocclusion, that is, it must The degree of involvement of the maxilla and mandible must be evaluated so that the treatment is directed to that bone base and achieves its objectives and impacts of facial improvement. Redirection of growth in Class III cases is indicated as soon as the anomaly is diagnosed, as the displacement processes that occur in the midface can only be affected with treatment as long as the growth zones can respond to the biomechanical stimulus. Therefore, the younger the Class III patient is treated, the better the facial correction effects will be.</p> Mayra Rodrigues Oliveira Geovanna Camarim de Oliveira Laura Ferro Borges Joice Melo Carlos Alberto Costa Neves Buchala Copyright (c) 2022 Mayra Rodrigues Oliveira, Geovanna Camarim de Oliveira, Laura Ferro Borges, Joice Melo, Carlos Alberto Costa Neves Buchala https://creativecommons.org/licenses/by/4.0 2022-12-26 2022-12-26 4 1 10.54448/mdnt22S613 Endodontic treatment and retreatment: a large systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/242 <p><strong>Introduction:</strong> In the context of treatment endodontics, endodontic surgery encompasses various procedures for the treatment of teeth with a history of endodontic treatment failures, such as apical surgery, crown and root resections, surgical repair of perforations, and intentional replantation. Endodontic microsurgery is the evolution of traditional apicectomy techniques and incorporates high magnification, ultrasonic preparation of the root end, and filling of the root end with biocompatible materials. <strong>Objective:</strong> It was to carry out a vast literature review in a systematic way to show the main considerations of endodontic treatment and retreatment. <strong>Methods:</strong> The systematic review rules of the PRISMA Platform were followed. The research was carried out from September to November 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument.<strong> Results and Conclusion:</strong> A total of 120 articles were found, and 75 articles were evaluated and 35 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 20 studies with a high risk of bias and 13 studies that did not meet GRADE. Most studies showed homogeneity in their results, with I2 =96.2% &gt;50%. Modern endodontic surgery uses the dental operating microscope and cone beam computed tomography for preoperative diagnosis and treatment planning. In the presence of persistent endodontic lesions or endodontic failure, endodontic treatment or endodontic surgery is required. In the long term, the risk of failure is identical for both groups, with only a slightly higher risk of failure for non-surgical endodontic retreatments when only two years of follow-up are considered.</p> Gabriela Pondian Alcalde Leticia Martins B de Paula Eduarda Nazaro de Paula Fábio Pereira Linhares de Castro Copyright (c) 2022 Gabriela Pondian Alcalde, Leticia Martins B de Paula, Eduarda Nazaro de Paula, Fábio Pereira Linhares de Castro https://creativecommons.org/licenses/by/4.0 2022-12-26 2022-12-26 4 1 10.54448/mdnt22S612 Protocol for obtaining and characterizing the stromal vascular fraction of human adipose tissue by mechanical dissociation: an original article https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/241 <p>The present technical study presented the mechanical dissociation protocol of adipose tissue from manual liposuction, as well as showed the immunobiological characterization (immunophenotyping), cell viability of the stromal vascular fraction of human adipose tissue, and cell concentration per milliliter. It was observed that the technique of the present study obtained a characterization yield of the stromal vascular fraction of the adipose tissue in terms of cell viability, cell concentration per milliliter, and immunophenotyping comparable and superior to most published studies with good scientific evidence.</p> Idiberto José Zotarelli Filho Fernanda Soubhia Liedtke Rafaella Scalabrini Ferrari Isabelle Dalloul Daher Eneidia Batista Neiva Malú Inês Perez Moura Ana Cristyna Saad Murad Copyright (c) 2022 Idiberto José Zotarelli Filho, Fernanda Soubhia Liedtke, Rafaella Scalabrini Ferrari, Isabelle Dalloul Daher, Eneidia Batista Neiva, Malú Inês Perez Moura, Ana Cristyna Saad Murad https://creativecommons.org/licenses/by/4.0 2022-12-26 2022-12-26 4 1 10.54448/mdnt22412 Major approaches to ozone therapy in endodontic treatments for bone infections and necrosis: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/240 <p><strong>Introduction:</strong> The bacterium Staphylococcus aureus is, in most cases, the agent of the disease. Thus, inflammation of the bone marrow can cause compression of the bone tissue walls and decrease or blockage of blood supply in the region's blood vessels, which can induce bone necrosis. Clinical studies have demonstrated the efficiency of ozone therapy in the treatment of peritonitis, infected wounds, and advanced ischemic disease. <strong>Objective:</strong> It was demonstrate the main scientific findings of the use of antiseptic ozone therapy in endodontic treatment. <strong>Methods:</strong> The research was carried out from July to October 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 127 articles were found, and 57 articles were evaluated and 29 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 10 studies with a high risk of bias and 28 studies that did not meet GRADE. Most studies showed homogeneity in their results, with I2 =96.8% &gt;50%. Ozone therapy is scientifically proven and demonstrated in this work, it proved to be effective for tissue repair and the prevention and treatment of bone necrosis. It was observed that patients undergoing chemotherapy, radiotherapy, and antiresorptive drugs are more affected by bone necrosis. It was also observed the importance of the patient feeling that the treatment works and is restoring his ability to reinvent himself and adapt to his social environment. Treatments should not only be based on established numbers and protocols, without analyzing the specific sensations and perceptions of each patient with their lived reality.</p> Maria Vitória da Costa Alves Azevedo Vitória Rodrigues Nunes Guilherme Fávaro Sbrogio Ana Paula Bernardes da Rosa Copyright (c) 2022 Maria Vitória da Costa Alves Azevedo, Vitória Rodrigues Nunes, Guilherme Fávaro Sbrogio, Ana Paula Bernardes da Rosa https://creativecommons.org/licenses/by/4.0 2022-12-05 2022-12-05 4 1 10.54448/mdnt22S611 Echoendoscopy-guided drainage of pancreatic collections using self-expanding metallic prosthesis: a retrospective observational cross-sectional study https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/239 <p><strong>Background:</strong> Pancreatic fluid collections are local complications of acute pancreatitis. Advances in research and the development of new techniques to address local complications have allowed minimally invasive therapeutic options. Endoscopic ultrasound-guided drainage is currently the procedure of choice. <strong>Objective:</strong> To describe the results of the placement of a self-expanding metallic prosthesis for echoendoscopy-guided drainage of pancreatic collections in patients. <strong>Methods:</strong> This study followed a retrospective observational cross-sectional model (STROBE rules). The study was sent and approved by the Institutional Ethics Committee of the Federal University of the State of Rio de Janeiro, Brazil. For data analysis, descriptive statistical analysis (mean and standard deviation), non-parametric analysis (Kruskal-Wallis, with p&lt;0.05 with a statistical difference in CI95%), and parametric analysis (One-Way Anova, with p&gt;0.05 with a statistical difference in CI95%), and logistic regression analysis, with p&lt;0.05 with statistical significance in CI95%. <strong>Results:</strong> Thirteen patients were referred for drainage of collections, and 4 patients were excluded. Of the 9 patients studied, there was a predominance of males (7:2) with a mean age of 54.5 years. Eight patients had walled-off necrosis (WON). The device used was the Hot AxiosTM self-expanding luminal apposition metallic prosthesis, which was inserted uneventfully in all patients. Complete resolution of the condition was found in 88.8% of cases. After logistic regression analysis between the categorical predictors (Gender and Age) versus the response predictors (Necrosectomy, Review Interval, and Stent Permanence), it was observed that certain Gender or Age can influence the response predictors. <strong>Conclusion:</strong> Drainage of pancreatic collections using minimally invasive techniques is a safe and effective procedure.</p> Luis Gustavo Santos Perissé Claudia Elizabeth Martinez Franco Rossano Kepler Alvim Fiorelli Paulo Cézar Marques Perissé Copyright (c) 2022 Luis Gustavo Santos Perissé, Claudia Elizabeth Martinez Franco, Rossano Kepler Alvim Fiorelli, Paulo Cézar Marques Perissé https://creativecommons.org/licenses/by/4.0 2022-11-25 2022-11-25 4 1 10.54448/mdnt22411 Crohn's disease with acute ileitis and its complications: a clinical case report https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/238 <p>Crohn's disease is a chronic, granulomatous inflammatory disease that can affect the entire gastrointestinal tract. Complications such as intestinal obstructions, fistula, or abscesses may determine the need for surgical treatment, with initial clinical stabilization. Therefore, the present work aimed to present a clinical case report, showing a patient who presented complications resulting from Crohn's disease to determine surgery as the definitive treatment and, emphasizes the importance of optimized treatment for this disease to avoid complications.</p> Adriel Contessotto Meneghello Beatriz Monteiro de Carvalho Cássio Alfred Brattig Cantão Cibele Alexandra Ferro Fernanda Magni Cadamuro Guilherme Gomes Romano Luiz Fernando Criscuolo Filho Mariah Menoci Mortean Matheus Shirane Wajima Rafael Moura Garcia Stephaní Martins de Oliveira Bruno Ziade Gil Copyright (c) 2022 Adriel Contessotto Meneghello, Beatriz Monteiro de Carvalho, Cássio Alfred Brattig Cantão, Cibele Alexandra Ferro, Fernanda Magni Cadamuro, Guilherme Gomes Romano, Luiz Fernando Criscuolo Filho, Mariah Menoci Mortean, Matheus Shirane Wajima, Rafael Moura Garcia, Stephaní Martins de Oliveira, Bruno Ziade Gil https://creativecommons.org/licenses/by/4.0 2022-11-23 2022-11-23 4 1 10.54448/mdnt22410 Quality of life of medicine students in the pandemic: a prospective observational cross-sectional study https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/237 <p>The COVID-19 pandemic has had major impacts on the mental and psychological health of young students. Stress, anxiety, depression, and a sedentary lifestyle are some of the consequences generated during the necessary social isolation. In this way, medical education has transformed due to the current Covid 19 epidemic, which has affected students and teachers of medical education in the country. In this way, the present research intends to collect data to evaluate the affected areas of the students in terms of quality of life, health, and other areas of their lives, thus being able to bring new information that can be used for a better approach to the theme. Therefore, this study evaluated the quality of life of medical students during the pandemic through the application of a remote questionnaire.</p> Alexandra Coelho Aguiari Camila Saggioro Paulucci Cibele Alexandra Ferro Felipe Roberto Trinco da Silva Floriano Alteia Costa Helena Burjaili Reiff Leonardo Paulino Ferreira Lívia Murasca Monteleone Luka Rogério Valentin Maria Laura Rodrigues Gastaldi Pedro Saggioro Paulucci Giovana Aparecida Gonçalves Vidotti Copyright (c) 2022 Alexandra Coelho Aguiari, Camila Saggioro Paulucci, Cibele Alexandra Ferro, Felipe Roberto Trinco da Silva, Floriano Alteia Costa, Helena Burjaili Reiff, Leonardo Paulino Ferreira, Lívia Murasca Monteleone, Luka Rogério Valentin, Maria Laura Rodrigues Gastaldi, Pedro Saggioro Paulucci, Giovana Aparecida Gonçalves Vidotti https://creativecommons.org/licenses/by/4.0 2022-11-23 2022-11-23 4 1 10.54448/mdnt22409 Main clinical evidence of ultrasound and ozone therapy in the endodontics treatments: the systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/235 <p><strong>Introduction:</strong> Issues related to endodontic treatment are intrinsically linked to the prevention and total control of pulp and periapical infections. The presence of microorganisms is not limited to the endodontic but is also present in the periradicular regions, characterized by an apical biofilm that is strongly adhered to the surface. In this context of decontamination of root and periapical canals, ozone has been highlighted as an important sanitizer. <strong>Objective:</strong> To demonstrate the main experimental and clinical findings of the use of ozone therapy alone and in association with conventional treatments as an antiseptic in the treatment of root canals. <strong>Methods:</strong> The research was carried out from May 2021 to June 2021 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar, following the Systematic Review-PRISMA rules. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results:</strong> There is moderate evidence to provide important preliminary information about ozone therapy. As for reducing the microbial load for patients undergoing root canal treatment, ozone therapy has inferior results when compared to conventional chemomechanical techniques using NaOCl. The joint action of these treatments proved to be quite effective. <strong>Conclusion:</strong> Ozone therapy is proving to be a useful new treatment modality that offers great benefits to patients. The strong antimicrobial power of ozone, together with its ability to stimulate the circulatory system and modulate the immune response, makes it a corrective agent of choice in the treatment of various oral infectious diseases. More research is needed to help with its reproducibility, its use should be indicated by the dentist in clinical practice.</p> Amanda da Fonseca Moraes Batista Fabiana Barcelos Ferreira Maisa Marques Rodrigues Fábio Pereira Linhares de Castro Copyright (c) 2022 Amanda da Fonseca Moraes Batista, Fabiana Barcelos Ferreira, Maisa Marques Rodrigues, Fábio Pereira Linhares de Castro https://creativecommons.org/licenses/by/4.0 2022-11-14 2022-11-14 4 1 10.54448/mdnt22S610 Major approaches and clinical findings of cataract surgery using the femtosecond laser: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/234 <p><strong>Introduction:</strong> In the scenario of eye problems, cataract is a disease characterized by the opacification of the lens, which leads to a decrease in visual acuity, due to a change in the refractive index. A cataract is the leading cause of blindness worldwide and surgery for its correction is the most performed surgical procedure in the world, with an estimated 19 million surgeries per year. The Femtosecond laser was approved for ophthalmic surgery in 2000, having been recently developed to integrate cataract surgery.<strong> Objective:</strong> It was to highlight the main clinical and scientific considerations related to the application of the Femtosecond laser in cataract surgery, highlighting its efficacy and safety to the conventional phacoemulsification technique. <strong>Methods:</strong> The systematic review rules of the PRISMA Platform were followed. The research was carried out from August to October 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, using articles from the last 15 years. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 229 articles were found, of which only 55 were part of this systematic review, after an eligibility analysis. Femtosecond laser-assisted cataract surgery appears to be beneficial in some patient groups, ie those with low baseline endothelial cell counts, or those planning to receive multifocal intraocular lenses. However, considering that the advantages of femtosecond laser-assisted cataract surgery may not be clear in all routine cases, it cannot be considered cost-effective. The adoption of the Femtosecond laser in cataract surgery has divided opinions as it results from the adaptation of a technology already used in other areas to a surgical procedure that, at the time, was already successful.</p> Ana Cristyna Saad Murad Isabelle Dalloul Daher Eneidia Batista Neiva Malú Inês Perez Moura Rafaella Scalabrini Ferrari Fernanda Soubhia Liedtke Copyright (c) 2022 Ana Cristyna Saad Murad, Isabelle Dalloul Daher, Eneidia Batista Neiva, Malú Inês Perez Moura, Rafaella Scalabrini Ferrari, Fernanda Soubhia Liedtke https://creativecommons.org/licenses/by/4.0 2022-11-14 2022-11-14 4 1 10.54448/mdnt22S609 Correlation of periodontal disease and complications of COVID-19: an integrative review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/233 <p>COVID-19 is a disease caused by a virus called SARS-CoV-2 that can cause damage to the lungs and other organs, of which most patients with COVID-19 have mild symptoms, however, some can develop serious illnesses such as pneumonia, edema lung disease, acute respiratory distress syndrome (ARDS), multiple organ dysfunction syndromes that can lead to death. In patients with compromised oral health who become infected with the SARS-CoV-2 virus, the virus can enter the systemic circulation of the periodontal pockets via gingival crevicular fluid (GCF) and then mix with saliva, or it can enter the systemic circulation via periodontal capillaries. In this way, the viruses associated with the periodontium can infect cells of the immune system that continually infiltrate the periodontal pocket. The literature reviews used and the observation of randomized studies were from the Bireme, PubMed, SciElo, and LILACS databases from 2007 to March 2021. To show that periodontal disease can further increase the release of cytokines via altered microflora, which cause complications in patients affected by Covid-19.</p> Victoria Possani Villa Maria Eduarda Ferreira Peron Mirilaini Lino Brancini Taylane Soffener Berlanga De Araújo Andréa Cândido dos Reis Copyright (c) 2022 Victoria Possani Villa, Maria Eduarda Ferreira Peron, Mirilaini Lino Brancini, Taylane Soffener Berlanga De Araújo, Andréa Cândido dos Reis https://creativecommons.org/licenses/by/4.0 2022-11-14 2022-11-14 4 1 10.54448/mdnt22S608 The advancement of adhesive dentistry with the endocrown technique and its diffusion among professionals: a literature review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/231 <p><strong>Introduction:</strong> In the decades with the advancement of materials fabrication, such as restorations with the latest improvements in their dental fabrication process, or as restorations with improvements in their dental fabrication process, or as the latest restorations in their dental fabrication process, dentistry, or as the latest restorations in their restorative materials manufacturing process. <strong>Objective:</strong> This work aims to demonstrate through a literature review the use of the endocrown technique. <strong>Methods:</strong> The research was carried out from January to May 2022 and was developed based on PubMed, Scielo, and Google Scholar. <strong>Results:</strong> There were 11 a total of 13 articles on Endocrowns. In total, 47 articles were complete and 19 were included in this study. Dentistry, contributing to a better resolution of cases, presents little interocclusal space, so the indirect endocrown restoration technique becomes an excellent option, presenting a good alternative and less dental wear for making. <strong>Conclusion:</strong> It was concluded that the use of the endocrown technique has shown, for the most part, employing clinical results that it is an excellent restorative option for the restoration of molars with great coronary destruction, and its clinical survival rate was comparable to the use of intraradicular posts of fiber.</p> Lucas Castilho Bazan Nayane Cristina de Faria Pedro Aryel Carvalho Dias Elias Naim Kassis Copyright (c) 2022 Lucas Castilho Bazan, Nayane Cristina de Faria, Pedro Aryel Carvalho Dias, Elias Naim Kassis https://creativecommons.org/licenses/by/4.0 2022-11-14 2022-11-14 4 1 10.54448/mdnt22S607 Perception of food patterns among adults using restrictive diets: a prospective observational cross-sectional study https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/230 <p><strong>Introduction:</strong> Obesity is a disease of increasing prevalence among adults in Brazil. It is an undesirable condition both from a health and an aesthetic point of view. The cult of the thin body sometimes motivates the adoption of restrictive diets, which significantly limit the menu. However, the use of this type of diet may be associated with unhealthy repercussions on food, well-being, and weight loss. <strong>Objective:</strong> To evaluate the perception of the dietary pattern of adult users of restrictive diets in a city in the northwest of São Paulo. <strong>Methods:</strong> Prospective observational cross-sectional study, carried out through an online questionnaire, with 108 subjects of both genders who perform/have already performed restrictive diets. <strong>Results:</strong> Predominance of female individuals (84.3%) aged between 18 and 21 years (49.1%). Regarding the Body Mass Index (BMI), 48.1% were classified within the normal range and 31.5% as preobese. In the period before the diet, 72.2% of the participants believed they were overweight. The beginning of the diet was motivated mainly by the desire to lose weight (87%) and its accomplishment happened, in most cases, without professional supervision (58.3%). Excessive eating episodes during the diet period were significant (only 14.8% never experienced it), with feelings of guilt associated in 71.3% of the cases. Conscious control during meals to avoid weight gain occurred with high frequency in 72.3% of cases. <strong>Conclusion:</strong> A portion of the population presents problematic perceptions about the experience with restrictive diets, which are associated with eating and psychological disorders.</p> Ana Beatriz Quinzani Baptista Beatriz e Silva Albani Carolina Santos Rodrigues Laura Carmona Figueiredo Mariana da Rocha Padovam Tainara Costa Durval Ribas Filho Copyright (c) 2022 Ana Beatriz Quinzani Baptista, Beatriz e Silva Albani, Carolina Santos Rodrigues, Laura Carmona Figueiredo, Mariana da Rocha Padovam, Tainara Costa, Durval Ribas Filho https://creativecommons.org/licenses/by/4.0 2022-11-14 2022-11-14 4 1 10.54448/mdnt22408 The impact of salary level on the diagnosis and treatment of children with cow's milk protein allergy: a prospective observational cross-sectional study https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/229 <p>Cow's milk protein allergy (CMPA) is a type of food allergy (FA), that is, a reaction of the immune system in the gastrointestinal tract due to the ingestion of proteins such as beta-lactoglobulin, alphalactalbumin, and casein. This condition most substantially affects children in the early stages of their development, about 2% of the American child population, and, consequently, directly or indirectly influences the families of each of them. In the Brazilian context, the epidemiological analysis is shallow in quantitative and qualitative data. Because of this, this study aims to understand the path of patients with CMPA, from diagnosis to treatment, and how their income and their knowledge of their rights in the Unified Health System interfere throughout this process. A form was used as a method to collect data from families with CMPA patients, accounting for 107 in all, which were consulted through online communities. Facing the financial and nutritional challenges of treating a child with CMPA and, at the same time, with the results obtained, the authors of this study were able to verify that, despite the high cost of adapting the diet of this AA, the economic factor was not it was relevant within this consulted microcosm regarding treatment, but slightly influential in the diagnosis. Analyzing the knowledge of the benefit offered by SUS concerning the child's nutritional supplementation, it was possible to verify that, of a total of 44 people, about 45%, know the benefit, but do not use it, and do not perform the supplementation. So, for this and other obtained relations, the study concluded that low income is not a limiting factor for the treatment of patients with CMPA, being slightly influential in the way in which families seek the diagnosis of this FA. In line with this view, it was possible to note the high evasion of SUS Primary Care and the non-use of the formulas offered, although they are sometimes known by the target audience.</p> Mariana Bayona Motta João Lucas Morete Caieiro da Costa Luca Campassi Bonini Rafael Ito Marques Vítor Pio de Queiroz Karina Dupim Marini Juliana Spir Barrionuevo Carolina Santos Rodrigues Copyright (c) 2022 Mariana Bayona Motta, João Lucas Morete Caieiro da Costa, Luca Campassi Bonini, Rafael Ito Marques, Vítor Pio de Queiroz, Karina Dupim Marini, Juliana Spir Barrionuevo, Carolina Santos Rodrigues https://creativecommons.org/licenses/by/4.0 2022-11-14 2022-11-14 4 1 10.54448/mdnt22407 Total collectomy in adult woman with Hirschsprung's Disease: a case report https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/228 <p>Hirschsprung's disease (HD) is a congenital anomaly of innervation of the lower intestine, limited to the colon, resulting from partial or total obstruction. The main symptom is the inability of a newborn to evacuate within 48 hours after birth, which can cause intestinal obstruction in the neonate and megacolon in children and adults. Therefore, this study reported the case of a 30-year-old female patient with HD affecting the entire colon, where we opted for surgical treatment. In the present study, it was emphasized the medical need to have a better understanding of the clinical picture of HD, as well as its complications and the importance of early diagnosis. In the report presented, it was discussed a late diagnosis of HD and how it affects the patient's life. It presented the improvement in the quality of life that can be obtained by offering an accurate diagnosis and adequate treatment for the patient.</p> Bárbara Beatriz Michelini Cibele Alexandra Ferro Enzo Prandi de Carvalho Fernanda Magni Cadamuro Luana Magni Cadamuro Luiz Fernando Criscuolo Filho Maria Clara Ferreira Vivi Marilia Siqueira Procopio de Oliveira Rafaela Melin Miranda Tacio Antônio Barros Silva Tayanne Fonseca Rodrigues Ayder Anselmo Gomes Vivi Copyright (c) 2022 Bárbara Beatriz Michelini, Cibele Alexandra Ferro, Enzo Prandi de Carvalho, Fernanda Magni Cadamuro, Luana Magni Cadamuro, Luiz Fernando Criscuolo Filho, Maria Clara Ferreira Vivi, Marilia Siqueira Procopio de Oliveira, Rafaela Melin Miranda, Tacio Antônio Barros Silva, Tayanne Fonseca Rodrigues, Ayder Anselmo Gomes Vivi https://creativecommons.org/licenses/by/4.0 2022-10-28 2022-10-28 4 1 10.54448/mdnt22406 Effect of S-PRG particles on demineralization and remineralization of dentin: a clinical case report https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/227 <p>It is known that the production of acid by oral bacteria dissolves mineral phases on the enamel surface, facilitating the formation of dental caries, with lactic acid being the main cause of caries, followed by acetic and propionic acids. Fluoride-containing materials play an important role in preventing demineralization and remineralization and these are widely used in dentistry. Although the benefits of fluoride in terms of reducing the incidence of dental caries are well established, fluoride cannot prevent caries in all patients; thus, the development of new anti-caries agents with remineralization properties is necessary. Thus, new products are emerging with this purpose and in this article, a material with Surface Pre Reacted Glass ionomer (S-PRG) particles will be addressed, these are produced by the acid-base reaction of fluoroboroaluminosilicate glass and polyacrylic acid and are known to have a potential to release 06 ions, such as Al, B, Na, Si, Sr and F, where these released ions played an important role in pH neutralization, leading to inhibition of enamel demineralization early point, where strontium (Sr) is becoming as a strong inducer of dentin matrix remineralization. Thus, this work aimed to demonstrate with a clinical case using S-PRG materials that can become an ally in the remineralization of the dental element. In conclusion, among the innovations that promote the concept of preventive and minimally invasive management, the bioactivity containing S-PRG can avoid invasive and definitive procedures such as tooth extraction.</p> Paula Silva Poletto Marcela Nunes Marin Mirilaini Lino Brancini Taylane Soffener Berlanga de Araújo Andréa Cândido dos Reis Copyright (c) 2022 Paula Silva Poletto, Marcela Nunes Marin, Mirilaini Lino Brancini, Taylane Soffener Berlanga de Araújo, Andréa Cândido dos Reis https://creativecommons.org/licenses/by/4.0 2022-10-28 2022-10-28 4 1 10.54448/mdnt22S606 Incisional hernia of giant abdominal wall: a case report https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/226 <p>Incisional hernia results from inadequate healing in the area of an operative incision and its diagnosis is clinical or imaging. Complex incisional hernias are difficult to treat and have complications, especially compartment syndrome. Thus, technical care in closing incisions in primary surgeries reduces the risk of developing an incisional hernia. Therefore, the study aimed to present a case report of a patient who performed the present correction of a giant incisional hernia with a double-sided mesh.</p> Beatriz Monteiro de Carvalho Cibele Alexandra Ferro Enzo Prandi de Carvalho Fernanda Magni Cadamuro João Pedro Pataro Domingos Leticia Remonte Righini Luana Magni Cadamuro Luiz Fernando Criscuolo Filho Maria Clara Ferreira Vivi Marilia Siqueira Procopio de Oliveira Tayanne Fonseca Rodrigues Ayder Anselmo Gomes Vivi Copyright (c) 2022 Beatriz Monteiro de Carvalho, Cibele Alexandra Ferro, Enzo Prandi de Carvalho, Fernanda Magni Cadamuro, João Pedro Pataro Domingos, Leticia Remonte Righini, Luana Magni Cadamuro, Luiz Fernando Criscuolo Filho, Maria Clara Ferreira Vivi, Marilia Siqueira Procopio de Oliveira, Tayanne Fonseca Rodrigues, Ayder Anselmo Gomes Vivi https://creativecommons.org/licenses/by/4.0 2022-10-28 2022-10-28 4 1 10.54448/mdnt22405 Major approaches to bone regeneration process with gut microbiota, exosomes, and microRNAs: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/225 <p><strong>Introduction:</strong> The incidence and mortality of bone diseases are still steadily increasing, creating a significant financial burden for societies across the world. To prevent the occurrence of bone diseases, slow their progression, or reverse the injuries they cause, new alternatives or complementary treatments need to be developed. The gut microbiota plays a role in bone metabolism and the pathogenesis of osteoporosis. <strong>Objective:</strong> It was to analyze through a systematic review the main considerations and clinical findings of the bone formation process through the modulation of the gut microbiota, as well as the functions of microRNAs and exosomes. Methods: The systematic review rules (PRISMA) were followed. The search was carried out from August to September 2022 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, using scientific articles from 2001 to 2022. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 126 articles were found. A total of 34 articles were fully evaluated and 26 were included in this systematic review. Most studies showed homogeneity in their results, with I2 =98.8%&gt;50%. The symmetrical funnel plot does not suggest a risk of bias between small sample-size studies. The gut microbiota plays an important role in the modulation of bone healing and bone health through the traffic of inflammatory TNF+ T and Th17 cells to the bone marrow, influencing the inflammatory state of the patient, determining the “brain-gut-bone” axis. It has been shown that the diversity of the gut microbiota is decreased in patients with osteoporosis, leading to a state of dysbiosis. There is a relationship between the microbiome, osteoblasts, osteoclasts, and nuclear factor ligand receptor-kappa-B (RANKL) activator. Studies have proposed several mechanisms of gut microbiome interaction with osteoclastogenesis and bone health, including microRNA, insulin-like growth factor 1, and immune system mediation. Therefore, bone regeneration requires that the basic biological principles of osteogenesis, osteoinduction, osteoconduction, and biocompatibility are followed.</p> Natasha Schlindwein Sarraceni Vitor Fujita Miyazaki Elias Naim Kassis Copyright (c) 2022 Natasha Schlindwein Sarraceni, Vitor Fujita Miyazaki, Elias Naim Kassis https://creativecommons.org/licenses/by/4.0 2022-10-28 2022-10-28 4 1 10.54448/mdnt22S605 Major randomized clinical studies of alopecia treatment with platelet-rich plasma: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/224 <p><strong>Introduction:</strong> Alopecia for men and women represents a significant problem worldwide, with around 600,000 hair restoration surgical procedures performed worldwide each year. Thus, the use of platelet-rich plasma (PRP) in regenerative medicine has been investigated for the treatment of alopecia. <strong>Objective:</strong> We performed a concise systematic review of the main clinical findings of the use of platelet-rich plasma for the treatment of alopecia. <strong>Methods:</strong> The systematic review rules of the PRISMA Platform were followed. The research was carried out from August to September 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. Scientific articles from the last 5 years were selected. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results:</strong> PRP was effective in increasing the proliferative activity of hair follicle cells and in increasing capillary density. In androgenetic alopecia, the addition of PRP with microneedling increased effectiveness and shortened the time required for optimal results, as did the combined use of PRP and minoxidil. <strong>Conclusion:</strong> According to the results of the main randomized controlled trials, platelet-rich plasma showed efficacy in increasing the proliferative activity of hair follicle cells and increasing capillary density.</p> Eneidia Batista Neiva Malú Inês Perez Moura Ana Cristyna Saad Murad Rafaella Scalabrini Ferrari Isabelle Dalloul Daher Fernanda Soubhia Liedtke Copyright (c) 2022 Eneidia Batista Neiva, Malú Inês Perez Moura, Ana Cristyna Saad Murad, Rafaella Scalabrini Ferrari, Isabelle Dalloul Daher, Fernanda Soubhia Liedtke https://creativecommons.org/licenses/by/4.0 2022-10-15 2022-10-15 4 1 10.54448/mdnt22404 Orthognathic surgery and fat injection for corrective liposculpture: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/223 <p><strong>Introduction:</strong> Orthognathic Surgery (OS) aims to correct deformities of the bones of the maxilla and mandible. In this scenario, fat grafting is a powerful tool for corrections and also for facial aesthetic improvement together or after OS. The benefits of fat grafting during orthognathic surgery; to maximize aesthetic results, minimize swelling and optimize wound healing. <strong>Objective:</strong> To analyze the main clinical studies on the benefits and risks of facial fat grafting in orthognathic surgery, to know the current state of the art. <strong>Methods:</strong> It followed a systematic literature review model on the main clinical findings of orthognathic surgery and fat grafting, according to the rules of PRISMA. The research was carried out from July to September 2022 and developed based on Google Scholar, Scopus, PubMed, Ovid, Scielo, and Cochrane Library, using scientific articles from 1986 to 2022. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results:</strong> 123 studies were analyzed, with only 32 medium and high-quality studies selected, according to GRADE rules, and with risks of bias that do not compromise scientific development, based on the Cochrane instrument. Studies have shown that OS aims to establish harmonious facial esthetics, excellent functional occlusion, and improved airway conditions. As an important adjunct to OS, fat grafting is becoming more and more common due to its antiinflammatory role and effects on facial swelling. High patient satisfaction with the results. Postoperative swelling resolved at week 12 in the fat graft group and persistent edema. The edema decrease over time, with almost complete resolution within 1 year, improvement in facial morphology, function, quality, and skin texture in most of their patients. The use of assisted lipo transfers containing mesenchymal stem cells derived from adipose tissue, enables improvement in skin quality, smoothing of wrinkles, pore size, and attenuation of pigmentation and resolution of scars. Furthermore, enrichment of the lipoaspirate with stem cells derived from adipose tissue increases graft retention. <strong>Conclusion:</strong> Most of the studies analyzed in this review study showed that fat grafting in orthognathic surgery is a safe and effective tool to improve wound healing, improve aesthetic results, present an anti-inflammatory effect and reduce edema.</p> Paulo Rodrigo Albino Lucchese Rogério Clayton Bisetto Fabio Alarcon Idalgo Silvio Antonio dos Santos Pereira Alexandre Gomes Nunes Elias Naim Kassis Álvaro José Cicareli Copyright (c) 2022 Paulo Rodrigo Albino Lucchese, Rogério Clayton Bisetto, Fabio Alarcon Idalgo, Silvio Antonio dos Santos Pereira, Alexandre Gomes Nunes, Elias Naim Kassis, Álvaro José Cicareli https://creativecommons.org/licenses/by/4.0 2022-10-15 2022-10-15 4 1 10.54448/mdnt22S604 Complicated acute diverticulitis: a clinical case report https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/222 <p>Diverticular disease is a benign disease, with a good response to clinical treatment, based on changes in eating habits, greater fiber consumption, potent antibiotic therapy in the simplest inflammatory processes, and the use of interventional radiology in abscesses. A surgical indication is restricted to failure of clinical therapy and more severe forms of the disease, such as strictures, abscesses, and perforations. The present study aimed to present a clinical case report on acute diverticulosis of the left colon that progressed to a reconstruction of the intestinal transit.</p> Bruna Mattos Cibele Alexandra Ferro Danilo Prandi de Carvalho Enzo Prandi de Carvalho Fernanda Magni Cadamuro Hugo Guerra Rozani João Pedro Pataro Domingos Marilia Siqueira Procopio de Oliveira Sidney Moreno Gil Bruno Ziade Gil Copyright (c) 2022 Bruna Mattos, Cibele Alexandra Ferro, Danilo Prandi de Carvalho, Enzo Prandi de Carvalho, Fernanda Magni Cadamuro, Hugo Guerra Rozani, João Pedro Pataro Domingos, Marilia Siqueira Procopio de Oliveira, Sidney Moreno Gil, Bruno Ziade Gil https://creativecommons.org/licenses/by/4.0 2022-10-14 2022-10-14 4 1 10.54448/mdnt22403 Incidence and major clinical approaches of aneurismatic bone cysts: a concise systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/221 <p><strong>Introduction:</strong> Aneurysmal bone cysts (ABC) are pseudocysts expansive lesions. The World Health Organization (WHO) categorizes primary ABCs as cystic neoplasms that contain fibrous septa separating numerous blood-filled spaces. Approximately 70% of ABC cases are primary, while 30% are secondary. <strong>Objective:</strong> The present study aimed to carry out a concise systematic review of the main clinical findings of aneurysmal bone cysts, highlighting the incidence and prevalence, as well as the main forms of treatment. <strong>Methods:</strong> The rules of the Systematic Review-PRISMA Platform were followed. The research was carried out from May 2022 to July 2022 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results:</strong> A total of 143 articles were found. In total, 73 articles were evaluated and 10 were included and evaluated in the systematic review. The symmetric funnel plot does not suggest a risk of bias. After prospecting the main literary findings, it was generally evidenced that the aneurysmal bone cyst (ABC) is a rare lesion that is more frequently found in young adults and children. It may have unpredictable behavior, with a high recurrence rate after treatment. Standard treatment consists of curettage plus local adjuvants and bone grafting to fill the void. In anatomic sites with difficult surgical access, percutaneous procedures are used (injection of sclerosing agents, radiofrequency thermal ablation, or selective arterial embolization. Medical management with bisphosphonates or denosumab has also been advocated. <strong>Conclusion:</strong> Primary ABCs involving the maxillofacial region are extremely rare and even more in patients with advanced age. Next-generation sequencing confirmed the presence of a USP6-CDH11 fusion gene, consistent with classification as a primary aneurysmal bone cyst. Sclerotherapy provided an effective and minimally invasive treatment for aneurysmal bone cysts and is particularly useful for deep injuries, challenging surgical access, and potentially injurious vital structures.</p> Amanda de Paula Vasconcelos Izabela Bryane Pereira Enderle Bannak Isabella Rodrigues Gomes Dias Naves Renato Gomes Azevedo Gestter Willian Lattari Tessarin Copyright (c) 2022 Amanda de Paula Vasconcelos, Izabela Bryane Pereira Enderle Bannak, Isabella Rodrigues Gomes Dias Naves, Renato Gomes Azevedo, Gestter Willian Lattari Tessarin https://creativecommons.org/licenses/by/4.0 2022-09-30 2022-09-30 4 1 10.54448/mdnt22S603 Relationship between diabetes, hypertension and periodontal diseases: a systematic review of major clinical findings https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/220 <p><strong>Introduction:</strong> In the scenario of periodontal diseases, chronic periodontitis is one of the most frequent periodontal diseases in the adult population with poor oral hygiene. The aggravating factors of the disease can be the occurrence of loss of bone structure, loss of attachment, and formation of a periodontal pocket, and even periodontitis can produce changes in systemic health, including stroke, renal failure, premature birth, diabetes, arterial hypertension, and coronary diseases. <strong>Objective:</strong> A concise systematic review was carried out to elucidate through clinical studies the real relationship between periodontal diseases, diabetes, and arterial hypertension. <strong>Methods:</strong> The rules of the Systematic Review-PRISMA Platform. The research was carried out from May 2022 to July 2022 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 127 articles were found. In total, 57 articles were fully evaluated and 18 were included and evaluated in this systematic review. The symmetric funnel plot does not suggest a risk of bias. An association between periodontitis and arterial hypertension was evidenced. Community oral care services provided by dental hygienists can promote objective oral hygiene and subjective periodontal status in the local community and can help manage hypertension and diabetes. An association of diabetes with increasing age was observed for the lowest social class. A statistically significant association between diabetes was also observed concerning individuals with hypertension, hypercholesterolemia, and periodontal disease. Yet, recent evidence suggests that periodontal disease causes hypertension. Diabetes mellitus is a factor that aggravates the periodontal disease. Periodontal treatment must be cautious and considered, and the periodontist must know the limitations, changes, and disorders that the diabetic patient may present. Any periodontal treatment should be performed once the diabetes is under control.</p> Isadora Mirella Gomes Mariano Ana Letícia Correa da Silveira Patrícia Garani Fernandes Copyright (c) 2022 Isadora Mirella Gomes Mariano, Ana Letícia Correa da Silveira, Patrícia Garani Fernandes https://creativecommons.org/licenses/by/4.0 2022-09-29 2022-09-29 4 1 10.54448/mdnt22S602