MedNEXT Journal of Medical and Health Sciences https://mednext.zotarellifilhoscientificworks.com/index.php/mednext <div class="row"> <div class="col-lg-2 journal-front"> <div class="journal-front-section-title-left"> </div> <img src="https://mednext.zotarellifilhoscientificworks.com/public/journals/1/journalThumbnail_en_US.jpg" alt="" width="150" height="211" /></div> <div class="col-lg-7 journal-front"> <div class="journal-front-section-title-left">Aim &amp; Scope</div> <p><strong>MedNEXT Journal of Medical and Health Sciences</strong> is an international, quarterly peer-reviewed, established in 2020, open-access online journal (E ISSN: 2763-5678) that publishes articles and video articles (optional) on topics related to all medical specialties, also in the various areas of health, and education in public health and medicine, including clinical, pre-clinical, experimental and translational studies, as well as review and meta-analysis studies.<br />Additionally, articles on alternative medicine, dentistry, nursing and related health sciences, veterinary sciences, teaching/educational methods in medical sciences, and artificial intelligence in medicine and health sciences are welcome. Interdisciplinary and transdisciplinary perspectives are also encouraged to integrate the fields of medical and health sciences. </p> <p><strong>MedNEXT Journal of Medical and Health Sciences</strong> requires that authors follow the ICMJE (International Committee of Medical Journal Editors) recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals. More information can be found here: <a href="http://www.icmje.org">ICMJE</a></p> </div> <div class="col-lg-3 journal-front"> <div class="journal-front-section-title">Journal Description</div> <div class="front-lef"> <p>Title: <strong> MedNEXT Journal of Medical and Health Sciences</strong> <br />E-ISSN: <strong><a title="2763-5678" href="https://portal.issn.org/resource/ISSN/2763-5678" target="_blank" rel="noopener">2763-5678</a></strong><br />Journal Abbreviation: <strong>MedNEXT J Med Health Sci</strong><br />Publication language: <strong>English</strong> <br />Publishing frequency: <strong>Quarterly (February, May, August, November)</strong><br />DOI Prefix: <strong><a title="10.54448" href="https://api.crossref.org/prefixes/10.54448/works" target="_blank" rel="noopener">10.54448</a></strong></p> <div class="journal-front-section-title">Social Network</div> <div class="front-lef"><center><a href="https://www.facebook.com/zotarellifilhoscientificworks" target="_blank" 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width="430" height="126" border="0" /></a></div> </div> <div class="col-lg-3"> <div class="journal-front-section-title">Archived In</div> <center> <img src="https://mednext.zotarellifilhoscientificworks.com/public/site/images/metasciencepresssupport3/issn.png" alt="" width="231" height="127" /></center><center><img src="https://mednext.zotarellifilhoscientificworks.com/public/site/images/metasciencepresssupport3/pkp.png" alt="" width="382" height="102" /></center></div> </div> </div> MetaScience Press en-US MedNEXT Journal of Medical and Health Sciences 2763-5678 <p><strong>1. Transfer of copyright:</strong></p> <p>The corresponding author or designee below, with the consent of all co-authors, hereby transfers to the publishers and copyright ownership in the referenced submitted work, including all versions in any format now known or hereafter developed and sell the articles worldwide in all languages and media (<u>Publishing Agreement &amp; Copyright Transfer Form</u>).</p> <p><strong>2. Rights and obligations of Publisher:</strong></p> <p>The Publisher’s rights to the Article shall especially include, but shall not be limited to:</p> <ul> <li>Ability to publish an electronic version of the Article via the website of the publisher or any other electronic format or means of electronic distribution provided by or through publisher from time to time, selling the Article world-wide (through subscriptions, Pay-per-View, single archive sale, etc.)</li> <li>Transforming to and selling the Article through any electronic format</li> <li>Publishing the Article in the printed Journals as listed on the official Website of Publisher</li> <li>Transferring the copyright and the right of use of the Article on to any third party</li> <li>Translating the Article in any language</li> <li>Taking measures on behalf of the Author against in fringement, in appropriate use of the Article, libel or plagiarism.</li> </ul> <p>Publishers agrees to send the text of the manuscript to the corresponding author e-mail address of Author indicated in the present Statement for preview before the first publishing either in paper and/or electronic format (Proof). Author should return the corrected test of the manuscript within 5 days to the publisher. Author shall, however, not make any change to the content of the Article during the First Proof preview.</p> <p><strong>3. Rights and obligations of Author:</strong></p> <p>The Author declares and warrants that he/she is the exclusive author of the Article– or has the right to represent all co-authors of the Article and has not granted any exclusive or non-exclusive right to the Article to any third party prior to the execution of the present Statement and has the right therefore to enter in to the present Statement and entitle the Publisher the use of the Article subject to the present Statement. By executing the present Statement Author confirms that the Article is free of plagiarism, and that Author has exercised reasonable care to ensure that it is accurate and, to the best of Author’s knowledge, does not contain any thing which is libellous, or obscene, or infringes on anyone’s copyright, right of privacy, or other rights. The Author expressively acknowledges and accepts that he/she shall been titled to no royalty (or any other fee) related to any use of the Article subject to the present Statement. The Author further accepts that he/she will not been titled to dispose of the copyright of the final, published version of the Article or make use of this version of the Article in any manner after the execution of the present Statement. The Author is entitled, however, to self-archive the preprint version of his/her manuscript. The preprint version is the Author’s manuscript or the galley proof or the Author’s manuscript along with the corrections made in the course of the peer-review process. The Author’s right to self-archive is irrespective of the format of the preprint (.doc, .tex., .pdf) version and self-archiving includes the free circulation of this file via e-mail or publication of this pre print on the Author’s web page or on the Author’s institution a repository with open or restricted access. When self-archiving a paper the Author should clearly declare that the archived file is not the final published version of the paper, he/she should quote the correct citation and enclose a link to the published paper<a href="https://www.ijpefs.com/index.php/(%20http:/dx.doi.org/"><em>( http://dx.doi.org/</em></a>[DOI of the Article without brackets]).</p> <p><strong>4. Use of third party content as part of the Article</strong></p> <p>When not indicating any co-authors in the present Statement Author confirms that he/she is the exclusive author of the Article. When indicating co- authors in the present Statement Author declares and warrants that all co-authors have been listed and Author has the exclusive and unlimited right to represent all the co-authors of the Article and to enter into the present Statement on their behalf and as a consequence all declarations made by Author in the present Statement are made in the name of the co-authors as well. Author also confirms that he/she shall hold Publisher harmless of all third-party claims in connection to non-authorized use of the Article by Publisher. Should Author wish to reuse material sourced from third parties such as other copyright holders, publishers, authors, etc. as part of the Article, Author bears responsibility for acquiring and clearing of the third party permissions for such use before submitting the Article to the Publisher for acceptance. Author shall hold Publisher harmless from all third party claims in connection to the unauthorized use of any material under legal protection forming a part of the Article.</p> <p><strong>5.Share with Colleagues:</strong></p> <p>Subject to the publishers, Authors may send or otherwise transmit electronic files of the Submitted or Accepted Work to interested colleagues prior to, or after, publication. Sharing of the Published Work with colleagues is permitted if it is done via the journal articles on Request author-directed link. The sharing of any version of the Work with colleagues is only permitted if it is done for non-commercial purposes; that no fee is charged; and that it is not done on a systematic basis, e.g. mass emailings, posting on a listserv, etc. Recipients should be informed that further redistribution of any version of the Work is not allowed. Authorized users of the publisher’s website may also email a link to the Author’s article directly to colleagues as well as <strong>recommend</strong> and share a link to the Author’s article with known colleagues through popular social networking services such as Facebook, Twitter, or CiteULike.</p> <p><strong>6. Retained Rights:</strong></p> <p>The Author(s) retain copyright and all other intellectual property rights.</p> <p><strong>Article Processing Fees</strong></p> <p>MedNEXT Journal of Medical and Health Sciences is an open access journal. Articles in the journal are free to access, download, share, and re-use. Also, we do not charge any submission charges from the authors. <br /><br /></p> <p><strong>Open Access Statement</strong></p> <p>Creative Commons Licenses<br />MedNEXT Journal of Medical and Health Sciences articles are published open access under a <a href="http://creativecommons.org/licenses/by/4.0/"><em>CC BY license</em></a> (Creative Commons Attribution 4.0 International License). The CC BY license allows for maximum dissemination and re-use of open access materials and is preferred by many research funding bodies. Under this license users are free to share (copy, distribute and transmit) and remix (adapt) the contribution including for commercial purposes, providing they attribute the contribution in the manner specified by the author or licensor (<a href="http://creativecommons.org/licenses/by/4.0/legalcode"><em>read full legal code</em></a>).<br />Under Creative Commons, authors retain copyright in their articles.</p> Major clinical outcomes of minimally traumatic and aesthetic post-tooth extraction: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/377 <p><strong>Introduction:</strong>&nbsp;After tooth extraction, the alveolar ridge will commonly decrease in volume and change morphologically. These changes can be&nbsp;difficult&nbsp;or even impede the placement of dental implants and prosthetic rehabilitation.&nbsp;Minimizing bone remodeling means optimizing the aesthetics and functional&nbsp;aspects,&nbsp;and&nbsp;mainly,&nbsp;the success of implant treatment.&nbsp;To avoid residual ridge resorption&nbsp;different&nbsp;techniques and bone graft materials have been proposed.&nbsp;<strong>Objective:</strong> A systematic review was carried out to identify the main clinical outcomes of minimally traumatic and aesthetic tooth extraction.&nbsp;<strong>Methods:</strong>&nbsp;The PRISMA Platform systematic review rules&nbsp;were followed.&nbsp;The search was&nbsp;carried out&nbsp;from January to February 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies&nbsp;was based&nbsp;on the GRADE instrument&nbsp;and&nbsp;the risk of bias was analyzed&nbsp;according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 189 articles&nbsp;were found, 45&nbsp;articles&nbsp;were evaluated&nbsp;in&nbsp;full&nbsp;and&nbsp;36 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 35 studies with a high risk of bias and 41&nbsp;studies&nbsp;that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X<sup>2</sup>=72.5%&gt;50%. The present study suggests that the alveolar graft technique may increase the risk of disease transmission, cost, and&nbsp;time of treatment. Several studies have stated that the graft material is not fully incorporated into the newly formed bone, indicating less vital bone tissue. Spontaneous scarring is still the most used feature since, in intact alveoli and&nbsp;small&nbsp;defects, it is a procedure that does not present significant losses that justify the use of edge preservation techniques. In&nbsp;larger&nbsp;defects, techniques after spontaneous healing, such as a block graft, can be used without the drawbacks of alveolar grafting, such as delayed healing and poor bone quality.&nbsp;The use of&nbsp;a buccal subepithelial connective tissue graft for extraction sockets in the anterior maxilla can be considered a predictable approach to preserving the contour of the alveolar ridge</p> Rebeca Rocha Martim Livia Alves Moreira Giovana Cezar Silva Andreia Borges Scriboni Copyright (c) 2024 Rebeca Rocha Martim, Livia Alves Moreira, Giovana Cezar Silva, Andreia Borges Scriboni https://creativecommons.org/licenses/by/4.0 2024-05-22 2024-05-22 5 S2 10.54448/mdnt24S210 Major considerations and outcomes of clinical studies on the treatment of temporomandibular disorders using prostheses: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/376 <p><strong>Introduction:</strong>&nbsp;The temporomandibular joint (TMJ) can be affected by end-stage pathologies, such as arthritic disease, trauma, and&nbsp;ankylosis. Around 70% of the general population has suffered at least one symptom of temporomandibular disorder (TMD), which constitutes TMJ disease that may be related to the joints, muscles, ligaments, bones, teeth, and psychological aspects. As a treatment,&nbsp;the implantation of&nbsp;a total alloplastic TMJ prosthesis is an innovative approach. <strong>Objective:</strong> It was to present the&nbsp;main&nbsp;considerations and outcomes of clinical studies on&nbsp;the treatments of&nbsp;temporomandibular disorders using customized or prefabricated prostheses. <strong>Methods:</strong> The PRISMA Platform systematic review rules&nbsp;were followed.&nbsp;The search was&nbsp;carried out&nbsp;from February to April 2024 in the Web of Science, Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies&nbsp;was based&nbsp;on the GRADE instrument&nbsp;and&nbsp;the risk of bias was analyzed&nbsp;according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 121 articles&nbsp;were found, 40&nbsp;articles&nbsp;were evaluated&nbsp;in&nbsp;full&nbsp;and&nbsp;21 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 22 studies with a high risk of bias and&nbsp;10&nbsp;studies&nbsp;that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X<sup>2</sup>=57.8%&gt;50%.&nbsp;It was concluded&nbsp;that stock and CAD/CAM prostheses suggested&nbsp;great&nbsp;improvements in mouth opening and pain reduction&nbsp;as a result of&nbsp;the rehabilitation of TMJ function. The results showed comparable data for both types of prosthesis design at&nbsp;6&nbsp;months postoperatively.&nbsp;However, the additional advantages of custom prosthetics, along with&nbsp;increasing access to digital technology,&nbsp;will likely result in custom devices dominating the market in TMJ total joint replacement systems.&nbsp;The&nbsp;custom-made&nbsp;combined prosthesis with custom design and 3D printing fabrication represents a safe and reliable implantable reconstruction method for combined TMJ-skull base injuries.</p> Vitor Eberharte Gubert Viccenzo Mercante Victor Hugo Bernardes Polidoro Janaina Cardoso Moreira Copyright (c) 2024 Vitor Eberharte Gubert, Viccenzo Mercante, Victor Hugo Bernardes Polidoro, Janaina Cardoso Moreira https://creativecommons.org/licenses/by/4.0 2024-05-21 2024-05-21 5 S2 10.54448/mdnt24S209 Dentistry and palliative care: a concise systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/375 <p><strong>Introduction:</strong>&nbsp;In recent decades, there has been a change in the age&nbsp;pyramid,&nbsp;through progressive population aging. This aging presents itself as a risk factor for several diseases, such as cancer and chronic degenerative diseases. Patients should be regularly questioned and evaluated regarding their oral health conditions. Patients in palliative care present severe functional restrictions and impairment of oral functions, which is even more common when the disease itself already affects the oral cavity, such as head and neck cancer.&nbsp;<strong>Objective:</strong> It was to carry out a systematic review to present the&nbsp;main&nbsp;considerations&nbsp;and clinical importance of palliative care in dentistry.&nbsp;<strong>Methods:</strong> The PRISMA Platform systematic review rules&nbsp;were followed.&nbsp;The search was&nbsp;carried out&nbsp;from&nbsp;January to March&nbsp;2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies&nbsp;was based&nbsp;on the GRADE instrument&nbsp;and&nbsp;the risk of bias was analyzed&nbsp;according to the Cochrane instrument. <strong>Results and Conclusion: </strong>Atotal of 129 articles were found, 45 articles were evaluated in full and 18 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 12 studies with a high risk of bias and 32 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X2=77.8%&gt;50%. It was concluded that understanding the importance of the dentist in caring for patients with diseases that threaten the continuity of life, through relieving suffering and promoting quality of life, based on oral health. Thus, with the work of the multidisciplinary health team, the patient, their family members, and caregivers will have adequate assistance, based on the particularities of each case.</p> Mayle Carla Coelho Pinto Juliana Pereira do Nascimento Letícia Ganzela Fiaschi Andreia Borges Scriboni Copyright (c) 2024 Mayle Carla Coelho Pinto, Juliana Pereira do Nascimento, Letícia Ganzela Fiaschi, Andreia Borges Scriboni https://creativecommons.org/licenses/by/4.0 2024-05-20 2024-05-20 5 S2 10.54448/mdnt24S208 Squamous cell carcinoma, are healthcare professionals prepared to identify it? A case report https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/374 <p>Squamous cell carcinoma (SCC), also known as squamous cell carcinoma, is a type of cancer that originates in the&nbsp;squamous cells of the skin&nbsp;and has different stages according to the involved cellular layer.&nbsp;In the early stage, the process begins with chronic sun exposure, leading to DNA damage in the squamous cells of the epidermis. Initiating&nbsp;in pre-cancerous lesions such as actinic keratosis, occurring in the outermost layers of the epidermis. In the intermediate stage, squamous cells undergo additional mutations, becoming cancerous but still restricted to the epithelial layer without invading deeper structures. While it is only in the epidermis, it is considered carcinoma in situ, as it is confined to this cellular layer and has not invaded the basement membrane. In the advanced stage, cancer cells invade the deeper layers of the epidermis, crossing the basement membrane, becoming basal cell cancer, and can reach the dermis. After reaching the dermis, cancer cells&nbsp;have the potential to&nbsp;spread to distant areas from the primary site, where the metastasis process begins and occurs, potentially affecting regional lymph nodes and other organs. In addition to the layers of the skin, cancer cells can spread to other tissues and organs, forming metastases that are cellular copies of their site of origin. At all stages, it is crucial to emphasize that the progression of squamous cell carcinoma involves progressive genetic mutations that confer malignant characteristics to the cells. Early diagnosis and treatment are essential to improve recovery prospects. Furthermore, prevention by avoiding alcohol,&nbsp;tobacco,&nbsp;and adequate sun protection plays a crucial role in reducing the risk of developing this type of cancer. Therefore, the present study aims to present a clinical case report on Labial Squamous Cell Carcinoma and the&nbsp;main&nbsp;considerations for preparing health professionals&nbsp;for the identification and diagnosis of&nbsp;LSCC.</p> David Hadson Arroyo Caio Bronca Maranini Elias Naim Kassis Igor Mariotto Beneti Copyright (c) 2024 David Hadson Arroyo, Caio Bronca Maranini, Elias Naim Kassis, Igor Mariotto Beneti https://creativecommons.org/licenses/by/4.0 2024-05-14 2024-05-14 5 S2 10.54448/mdnt24S207 Mental health status among corporate- and public sector health care workers in India during COVID-19 pandemic (second-wave): Impact of awareness, work satisfaction, risky work-environment practices and social media usage on DASS-21 & IES-R scores https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/373 <p><strong>Introduction:</strong> With the advent of coronavirus pandemic, health care workers (HCWs) faced numerous professional, financial, and emotional challenges in addition to social stigma. <strong>Objective:</strong> It was intended to analyse the correlation of depression, anxiety, and stress among corporate and public sector HCWs, with awareness, risky work environment practises, work-environment satisfaction and social media preferences. <strong>Materials and Methods: </strong>Doctors, nurses and paramedical staff in critical care, obstetrics, neuro-anaesthesia and neurosurgery wards/ICUs in a public and corporate sector hospital were administered DASS-21 (depression-anxiety-stress scale), IES-R (impact of event scale-revised) and a common perception-based survey to assess the HCW awareness (AWA), work environment satisfaction (WES), risky work environment practises (RWE) and social media preferences (SM scale). <strong>Results: </strong>In corporate sector, being a nurse correlated with higher scores of stress (<em>rs =1, p=0</em>), DASS (<em>rs =0.34,</em> p=.114), depression (<em>rs =0.54, p=.007</em>), anxiety (<em>rs</em> =0.42<em>, p=.041</em>) and IES-R (<em>rs</em> =0.34, p=0.13). SM score negatively correlated with anxiety (<em>rs</em> =0.58, <em>p=0.045</em>), stress (<em>rs</em> =0.418, <em>p=.041</em>), DASS (<em>rs</em> =0.62, <em>p=.001</em>) and IES-R (<em>rs</em> =0.45, <em>p=.031</em>). In public sector, female HCWs had higher DASS (t=2.61,<em> p=.018</em>), anxiety (t=2.2,<em> p=.03</em>), stress (t=-2.11,<em> p=.011</em>) and IES-R (t=-1.86, p=0.07). AWA score negatively correlated with anxiety (R=-0.56, <em>p= .005</em>), DASS (rs=-0.48, <em>p=.004</em>) depression (p= .283), stress (p= .11) and IES-R (p= .101). RWE score strongly correlated with anxiety (<em>rs</em> =0.39, <em>p= .027</em>). Depression (D <em>total</em>, <em>p= .010</em>) and IES-R (<em>p= .024</em>) were significantly higher in public sector HCWs. Anxiety (A <em>total</em>, p= .108) and stress (S <em>total, </em>p= .246) were lower in corporate sector HCWs. <strong>Conclusion: </strong>Corporate sector nurses and female HCWs in the public sector showed significantly higher stress, depression, and anxiety scores. Increasing awareness about disease could mitigate stress, anxiety, and depression while prevailing social media preferences aggravate anxiety, stress, and depression.</p> Sanjeev Sreenivasan Neha Agarwal Samir Parikh Preeti Singh Rana Patir Sudipta Roychowdhury Gaurav Gupta Copyright (c) 2024 Sanjeev Sreenivasan, Neha Agarwal, Samir Parikh, Preeti Singh, Rana Patir, Sudipta Roychowdhury, Gaurav Gupta https://creativecommons.org/licenses/by/4.0 2024-05-06 2024-05-06 5 S2 10.54448/mdnt24208 Major considerations and outcomes of clinical studies on the treatment of temporomandibular disorders using prostheses: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/372 <p><strong>Introduction:</strong> The temporomandibular joint (TMJ) can be affected by end-stage pathologies, such as arthritic disease, trauma, and ankylosis. Around 70% of the general population has suffered at least one symptom of temporomandibular disorder (TMD), which constitutes TMJ disease that may be related to the joints, muscles, ligaments, bones, teeth, and psychological aspects. As a treatment, the implantation of a total alloplastic TMJ prosthesis is an innovative approach. <strong>Objective:</strong> It was to present the main considerations and outcomes of clinical studies on the treatments of temporomandibular disorders using customized or prefabricated prostheses. <strong>Methods:</strong> The PRISMA Platform systematic review rules were followed. The search was carried out from February to April 2024 in the Web of Science, Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 121 articles were found, 40 articles were evaluated in full and 21 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 22 studies with a high risk of bias and 10 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X<sup>2</sup>=57.8%&gt;50%. It was concluded that stock and CAD/CAM prostheses suggested great improvements in mouth opening and pain reduction as a result of the rehabilitation of TMJ function. The results showed comparable data for both types of prosthesis design at 6 months postoperatively. However, the additional advantages of custom prosthetics, along with increasing access to digital technology, will likely result in custom devices dominating the market in TMJ total joint replacement systems. The custom-made combined prosthesis with custom design and 3D printing fabrication represents a safe and reliable implantable reconstruction method for combined TMJ-skull base injuries.</p> Vitor Eberharte Gubert Viccenzo Mercante Victor Hugo Bernardes Polidoro Janaina Cardoso Moreira Copyright (c) 2024 Vitor Eberharte Gubert, Viccenzo Mercante, Victor Hugo Bernardes Polidoro, Janaina Cardoso Moreira https://creativecommons.org/licenses/by/4.0 2024-05-06 2024-05-06 5 S2 10.54448/mdnt24207 Optimization of facial aesthetics through orthognathic treatment: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/371 <p><strong>Introduction:</strong> In the aesthetics scenario, facial optimization is considered an essential outcome of orthognathic treatment (OT) due to its potential advantages in reducing the duration and cost of treatment, providing early aesthetic improvement, and increasing patient satisfaction. <strong>Objective:</strong> It presents a systematic review study listing the main optimizations of facial aesthetics through orthognathic surgery, to highlight the importance of this treatment for improving patients' comfort and quality of life. <strong>Methods:</strong> The PRISMA Platform systematic review rules were followed. The search was carried out from January to March 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 179 articles were found, 45 articles were evaluated in full and 39 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 15 studies with a high risk of bias and 31 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X<sup>2</sup>=69.5%&gt;50%. It was concluded space maintenance is one of the most important activities in the prevention of malocclusion. The maintenance of the lost space is of paramount importance to ensure normal eruption and development of the dentition. Aesthetic/functional rehabilitation is necessary until the eruption of permanent successor teeth occurs. A practical option to obtain this rehabilitation is through the installation of aesthetic or functional space maintainers. There are several requirements, such as maintaining the desired interproximal space, not interfering with the occlusion of the opposing teeth nor with the eruption of the permanent tooth, allowing sufficient mesiodistal space for the permanent tooth alignment to erupt, not inferring in phonetics and chewing and present a simple framework and be easily sanitized. Thus, the neuromuscular stability of the stomatognathic system may be impaired by the presence of deleterious habits.</p> Laiane Martins dos Santos Maria Fernanda Trevisan Machado Monique Scavassa de Souza Roversi Andreia Borges Scriboni Copyright (c) 2024 Laiane Martins dos Santos, Fernanda Trevisan Machado, Monique Scavassa de Souza Roversi, Andreia Borges Scriboni https://creativecommons.org/licenses/by/4.0 2024-04-23 2024-04-23 5 S2 10.54448/mdnt24206 Major evidence of the relationship of cardiovascular disease and tooth extraction: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/370 <p><strong>Introduction:</strong> Cardiovascular diseases can present a congenital origin, that is present from birth, such as interatrial and interventricular communication, defects of the artery, coronary arteries, or acquired coronary artery anomalies that involve several risk factors such as smoking, alcohol, old age, and sedentary lifestyle. Thus, the acquired ones are the most frequent in the routine of a dental practice, so the dentist should be able to attend to those patients who need special care, regarding the correct use of medications due to the risk of drug interactions, the type of local anesthetic to be used and the management of patients who use anticoagulant therapy.<strong> Objective: </strong>It was to develop a concise systematic review to highlight the main clinical outcomes of the relationship between cardiovascular diseases and tooth extraction. <strong>Methods:</strong> The research and development of the work were carried out from December 2023 to February 2024 in the databases Scopus, PubMed, Science Direct, and Scielo, following the PRISMA rules. The quality of the studies was based on the GRADE instrument and the risk of bias was based on the Cochrane instrument (Funnel Plot). <strong>Results and Conclusion:</strong> A total of 112 studies were found that were subjected to eligibility analysis. The final sample had 36 eligible studies and 21 studies were described in the systematic review. Most studies showed homogeneity in their results, with X<sup>2</sup> =63.9% &gt;50%, with p&lt;0.05. It was concluded that the virtual reality technique was effective in controlling blood pressure and heart rate within an acceptable range and can help in the management of blood pressure and heart rate during tooth extraction in patients with hypertension. It is necessary for the dental treatment of these patients with heart disease a good knowledge of the subject and requires medical and dental coordination. Dental surgeons need to be prepared to identify possible medical and dental emergencies and take steps to prevent or treat them effectively and quickly.</p> Maria Angélica Tognolo Taise Pianesso Heloísa Soler Gomes Andreia Borges Scriboni Copyright (c) 2024 Maria Angélica Tognolo, Taise Pianesso, Heloísa Soler Gomes, Andreia Borges Scriboni https://creativecommons.org/licenses/by/4.0 2024-03-27 2024-03-27 5 S2 10.54448/mdnt24S206 Major clinical approaches to tooth whitening techniques and differences in terms of sensitivity and protection: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/369 <p><span class="fontstyle0"><strong>Introduction:</strong> </span><span class="fontstyle2">Tooth whitening is an initial step in the analysis and reproduction of the aesthetics of the smile, so the dentist must know how to diagnose the causes of color changes, and recommend whitening before proposing the appropriate dental procedure. With technological advances, tooth whitening techniques have emerged to facilitate their use improve comfort and safety, and reduce time spent performing the technique. The conventional means of external tooth whitening is with carbamide peroxides or light-activated hydrogen or not. However, both at-home and in-office whitening procedures cause tooth sensitivity. There is a new whitening proposal on the market without the use of whitening gels, thus reducing post-treatment sensitivity. This proposal highlights ultraviolet light as a whitening agent. </span><strong><span class="fontstyle0">Objective: </span></strong><span class="fontstyle2">It was to carry out a concise systematic review of the main clinical approaches to tooth whitening techniques, to point out the differences between them in terms of sensitivity and tooth protection. </span><span class="fontstyle0"><strong>Methods:</strong> </span><span class="fontstyle2">The PRISMA Platform systematic review rules were followed. The search was carried out from January to February 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. </span><strong><span class="fontstyle0">Results and Conclusion: </span></strong><span class="fontstyle2">A total of 178 articles were found, 40 articles were evaluated in full and 20 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the&nbsp;</span><span class="fontstyle2">overall assessment resulted in 21 studies with a high risk of bias and 31 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X</span><span class="fontstyle2">2</span><span class="fontstyle2">=67.4%&gt;50%. It was concluded that tooth whitening can be indicated in practically all situations in which tooth darkening occurs, such as pulp tissue decomposition, internal hemorrhage, trauma, use of medications, restorative materials, and systemic conditions such as fluorosis, jaundice, and fetal erythroblastosis, among others. others. Contraindications for tooth whitening treatment occur in children under 10 years of age. Whitening using the home technique uses products with lower concentrations, between 10% and 22% carbamide peroxide. In-office, 16% carbamide peroxide was effective. In office-based tooth whitening, higher concentrations of whitening substances are used and laser, LED, ultraviolet, and halogen light can be used to intensify the whitening process. Patients undergoing vital teeth whitening report sensitivity or discomfort during treatment. Oxidative stress generated by bleaching agents can cause apoptosis and damage to periodontium DNA (genotoxicity) and cellular cytotoxicity. A new generation of whitening agents with low concentrations of hydrogen peroxide (3.5% and 15%) was introduced on the market for in-office teeth whitening, aiming to achieve greater safety and efficiency in tooth whitening.</span> </p> Drica Garcia Zanelatto Janaina Cardoso Moreira Copyright (c) 2024 Drica Garcia Zanelatto, Janaina Cardoso Moreira https://creativecommons.org/licenses/by/4.0 2024-03-26 2024-03-26 5 S2 10.54448/mdnt24204 Major clinical outcomes of the alveolar ridge preservation post-extraction sockets: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/366 <p><strong>Introduction:</strong> After tooth extraction, the alveolar ridge will commonly decrease in volume and change morphologically. These changes can be difficult or even impede the placement of dental implants and prosthetic rehabilitation. Minimizing bone remodeling means optimizing the esthetics and functional aspects, and mainly, the success of implant treatment. To avoid residual ridge resorption different techniques and bone graft materials have been proposed. <strong>Objective:</strong> <strong>&nbsp;It was </strong>to evaluate the efficiency of the many techniques of extraction socket treatment in the alveolar ridge dimension preservation. <strong>Methods:</strong> The PRISMA Platform systematic review rules were followed. The search was carried out from November 2023 to February 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 158 articles were found, 62 articles were evaluated in full and 34 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 28 studies with a high risk of bias and 22 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X<sup>2</sup>=63.6%&gt;50%. It was concluded that the application of autologous growth factor concentrate after surgical extraction offers an easy, low-cost, and efficient option for preserving the alveolar ridge. Therefore, the use of autologous growth factor concentrate by dentists during tooth extractions can be encouraged, especially when preservation of the alveolar ridge is necessary. The present study suggests that the alveolar graft technique may increase the risk of disease transmission, cost, and time of treatment. Several studies have stated that the graft material is not fully incorporated into the newly formed bone, indicating less vital bone tissue. Spontaneous scarring is still the most used feature since, in intact alveoli and small defects, it is a procedure that does not present significant losses that justify the use of edge preservation techniques. In larger defects, techniques after spontaneous healing, such as a block graft, can be used without the drawbacks of alveolar grafting, such as delayed healing and poor bone qualit.</p> Isabelly Lima Rocha Monaliza de Souza Amorim Nathalia Martinez Tigre Andreia Borges Scriboni Copyright (c) 2024 Isabelly Lima Rocha, Monaliza de Souza Amorim, Nathalia Martinez Tigre, Andreia Borges Scriboni https://creativecommons.org/licenses/by/4.0 2024-03-23 2024-03-23 5 S2 10.54448/mdnt24S205 Major clinical approaches of dental treatment in cancer patients: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/365 <p><strong>Introduction:</strong> According to the National Cancer Institute, a total of 16,290 new cases of oral cancer were estimated in Brazil in 2017, with 12,370 new cases of oral cavity cancer in men and 4,010 in women corresponding to an estimated risk of 11.54 cases new for every 100 thousand men and 3.92 for each 100 thousand women. In this sense, oral cancer therapy is associated with a multitude of head and neck sequelae including hyposalivation, increased risk of tooth decay, osteoradionecrosis of the jaw, radiation fibrosis syndrome, mucositis, chemotherapy-induced neuropathy, dysgeusia, dysphagia, mucosal lesions, trismus, and infections. <strong>Objective:</strong> It was to present the main clinical approaches to dental treatment in cancer patients through a systematic review. <strong>Methods:</strong> The PRISMA Platform systematic review rules were followed. The search was carried out from November 2023 to February 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 156 articles were found, 58 articles were evaluated in full and 29 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 32 studies with a high risk of bias and 20 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X2=61.8%&gt;50%. It was concluded that preparing a comprehensive treatment plan for cancer patients is essential to help minimize the risks of developing these oral and dental complications. Additionally, dentists should consider the patient's ongoing oncology therapy for those patients who see the dentist while receiving cancer treatment.</p> Mylena Gabrielly Neves Silva Rosimeire soares Mendes Moreira Laura Padoan Groto Carlos Alberto Costa Neves Buchala Copyright (c) 2024 Mylena Gabrielly Neves Silva, Rosimeire soares Mendes Moreira, Laura Padoan Groto, Carlos Alberto Costa Neves Buchala https://creativecommons.org/licenses/by/4.0 2024-03-18 2024-03-18 5 S2 10.54448/mdnt24S204 Main processes of bone formation and regeneration through molecules and cells as biostimulators in buccomaxillofacial surgery: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/364 <p><strong>Introduction:</strong> At a cellular and molecular level, tissue engineering offers numerous advantages that meet the needs of the injured tissue or organ for the bone regeneration process in buccomaxillofacial surgeries. To achieve this, it is necessary to understand the chemical, physical, and biological processes of both the biological material and the target biological niche. <strong>Objective:</strong> It was to carry out a concise systematic review of the main processes of bone formation and regeneration using molecules and cells as biostimulators in buccomaxillofacial surgeries. <strong>Methods: </strong>The PRISMA Platform systematic review rules were followed. The search was carried out from December 2023 to February 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 182 articles were found, 60 articles were evaluated in full and 36 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 12 studies with a high risk of bias and 20 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X<sup>2</sup>=54.7%&gt;50%. The bone regeneration process occurs through the activation of osteoblasts and vascular control guided by PDGFs and TGF-β. These growth factors also promote matrix formation and osteoblast differentiation. Some biodegradable natural polymers (chitosan®) associated with inorganic materials such as tricalcium phosphate were tested as spongy carriers for PDGF-BB. Chitosan® has been attributed to hemostatic properties, inducing bone formation and regulating the release of bioactive agents. The use of platelet-rich plasma and mesenchymal stem cells (exosomes and microRNAs) has been indicated and used in other areas of oral and buccomaxillofacial surgery, accelerating a process of bone regeneration that normally already occurs and this process continues its path until the formation of bone mature.</p> Luís Fernando Inada Igor Mariotto Beneti Copyright (c) 2024 Luís Fernando Inada, Igor Mariotto Beneti https://creativecommons.org/licenses/by/4.0 2024-03-12 2024-03-12 5 S2 10.54448/mdnt24S203 Use of platelet-rich plasma isolated or in combination in osteoarthritis of the temporomandibular joint: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/363 <p><strong>Introduction:</strong> Temporomandibular joint osteoarthritis (TMJ-OA) is a common disease in the oral and maxillofacial regions and is the most serious type. Among temporomandibular disorders, TMJ-OA accounts for 18% to 85% of all cases. The use of platelet-rich plasma (PRP) has been highlighted, as well as in combination with other types of treatments such as hyaluronic acid, arthrocentesis, and corticosteroids. <strong>Objective: </strong>to highlight the main clinical outcomes of the treatment of osteoarthritis of the temporomandibular joint through the injectable use of platelet-rich plasma, alone or in combination with other types of treatment. <strong>Methods:</strong> The research and development of the work were carried out from December 2023 to February 2024 in the databases Scopus, PubMed, Science Direct, and Scielo, using scientific articles from 2013 to 2023, following the PRISMA rules. The quality of the studies was based on the GRADE instrument and the risk of bias was based on the Cochrane instrument (Funnel Plot). <strong>Results and Conclusion:</strong> A total of 178 studies were found that were subjected to eligibility analysis. The final sample had 45 eligible studies and 31 studies were described in the systematic review. Most studies showed homogeneity in their results, with X<sup>2</sup> =66.7% &gt;50%, with p&lt;0.05. The symmetric funnel plot did not suggest a risk of bias among studies with a small sample size. The results showed that platelet-rich plasma performed better than hyaluronic acid in the treatment of osteoarthritis of the temporomandibular joint during longterm follow-up in terms of reducing pain and increasing interincisal distance. Combined injection of hyaluronic acid and platelet-rich plasma after arthrocentesis is more effective than hyaluronic acid or platelet-rich plasma alone in the treatment of osteoarthritis of the temporomandibular joint, as well as platelet-rich plasma with hyaluronic acid after arthrocentesis showed significant clinical efficacy long-term concerning pain relief. Furthermore, it was found that intra-articular injections of platelet-rich plasma reduced pain on palpation of the temporomandibular joint more effectively compared to hyaluronic acid and corticosteroids. Platelet-rich plasma injection can significantly improve pain, mouth opening, abnormal joint sound, and jaw function in patients with temporomandibular joint osteoarthritis, and has a good repair effect on condylar bone defects. Furthermore, platelet-rich plasma injection combined with physical therapy can effectively control medium and long-term pain in patients.</p> Paulo Cesar dos Santos Priscila Silva Perecin Hellen Kkathleen Lima de Oliveira Silva Andreia Borges Scriboni Copyright (c) 2024 Paulo Cesar dos Santos, Priscila Silva Perecin, Hellen Kkathleen Lima de Oliveira Silva, Andreia Borges Scriboni https://creativecommons.org/licenses/by/4.0 2024-03-11 2024-03-11 5 S2 10.54448/mdnt24S202 Clinical results of orthognatic surgery in the treatment of obstructive sleep apnea syndrome: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/362 <p><strong>Introduction:</strong> Obstructive sleep apnea syndrome (OSAS) is characterized by intermittent partial or complete obstruction of the airways during sleep and is called OSAS syndrome when associated with day/night symptoms and/or comorbidities, such as systemic arterial hypertension or diabetes mellitus. The prevalence reaches 32% in the general population, varies between 1% and 20% when associated with COPD (overlap syndrome), and is described as above 60% in populations with COPD and obesity. Orthognathic surgery (OC) can correct deformities of the maxillary and mandibular bones in OSAS. <strong>Objective:</strong> It was to develop the main approaches and clinical results of orthognathic surgery for the treatment of obstructive sleep apnea syndrome through a systematic review. <strong>Methods:</strong> The PRISMA Platform systematic review rules were followed. The search was carried out from November 2023 to February 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> 146 articles were found, 58 articles were evaluated and 26 were included in this systematic review. Considering the Cochrane tool for risk of bias, the global assessment resulted in 32 studies with a high risk of bias and 22 studies that did not meet GRADE. Most studies showed homogeneity in their results, with X<sup>2</sup> =65.8%&gt;50%. Maxillomandibular advancement surgery is a successful treatment for obstructive sleep apnea, but there are still concerns about cosmetic results due to the major advances involved. Bimaxillary advancement osteotomy significantly increases oropharyngeal volume and contracted superficial areas, which remain stable between 6 months and 1 year postoperatively.</p> Ingrid Caroline de Carvalho Ferreira Hellen de Oliveira Cavatão Isadora Scarlatto Magalhães Andreia Borges Scriboni Copyright (c) 2024 Ingrid Caroline de Carvalho Ferreira, Hellen de Oliveira Cavatão, Isadora Scarlatto Magalhães, Andreia Borges Scriboni https://creativecommons.org/licenses/by/4.0 2024-03-11 2024-03-11 5 S2 10.54448/mdnt24S201 Major clinical approaches at the aesthetic level and complications of bichectomy: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/361 <p><strong>Introduction:</strong> According to the Brazilian Society of Plastic Surgery in 2016, 7,362 people underwent bichectomy (BC), which represents 0.5% of the total number of aesthetic surgeries. In an attempt to achieve facial harmonization, BC surgery presents little complexity and is based on some well-defined steps. Even when appropriately indicated, it is still a controversial procedure, as there is no surgical technique adequately systematized in current literature, aiming to make it safe and reproducible. <strong>Objective:</strong> It was to present the main aesthetic considerations and complications of bichectomy, as well as discuss its safe management to avoid and treat problems. <strong>Methods:</strong> The PRISMA Platform systematic review rules were followed. The search was carried out from November 2023 to February 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 96 articles were found, 40 articles were evaluated in full and 28 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 12 studies with a high risk of bias and 10 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X<sup>2</sup>=67.9%&gt;50%. It was concluded that on an aesthetic level, performing a bichectomy thins the middle third of the face, outlining and highlighting the bone angulations of the zygomatic region, contributing to a more pleasant facial aesthetics. Surgical removal of the Bichat ball induces a mild inflammatory process controlled by rescue medication, significantly reduces facial volume, and improves the quality of life and satisfaction with facial aesthetics 3 months postoperatively. Several studies have presented the importance of using the Bichat ball as an oral layer to close fistulas and also to cover bone grafts in implant dentistry.</p> Laura Ribeiro Miriane Plaza Silva Nathalia Zaguine Ravasoli Andreia Borges Scriboni Copyright (c) 2024 Laura Ribeiro, Miriane Plaza Silva, Nathalia Zaguine Ravasoli, Andreia Borges Scriboni https://creativecommons.org/licenses/by/4.0 2024-03-08 2024-03-08 5 S2 10.54448/mdnt24201 Major clinical outcomes of laser therapy in endodontic treatments: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/360 <p><strong>Introduction:</strong> In the setting of endodontic treatment, postoperative pain continues to be a problem in up to 58% of patients. This is due to the release of inflammatory mediators whenever the pulp or periradicular tissues are injured during root canal treatment or retreatment. The application of lasers in endodontics has increased due to their safety and effectiveness in dental treatments. <strong>Objective:</strong> It was to develop a systematic review to present the main clinical outcomes of the use of laser therapy in endodontic treatments. <strong>Methods:</strong> The PRISMA Platform systematic review rules were followed. The search was carried out from December 2023 to January 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 98 articles were found, 35 articles were evaluated in full and 20 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 21 studies with a high risk of bias and 26 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X<sup>2</sup>=72.7% &lt;50%. It was concluded that low-level laser therapy has been used in endodontics to promote analgesia, modulation of inflammation, and tissue healing. Analgesia mediated by low-level laser therapy results in vasodilation, and increased levels of adenosine triphosphate and cortisol, inhibiting the production of inflammatory factors. Recent studies reported that the use of low-level lasers enabled the treatment of post-endodontic pain compared to control. Furthermore, studies have shown that laser therapy can increase collagen synthesis and, concerning bone, modulate inflammation, accelerate cell proliferation, as well as stimulate bone stem cells, and accelerate their repair process.</p> Nayra Roberta Coculo Santos Beatriz Mansur Tertuliano Oscar Pires Copyright (c) 2023 Nayra Roberta Coculo Santos, Beatriz Mansur Tertuliano, Oscar Pires https://creativecommons.org/licenses/by/4.0 2024-03-05 2024-03-05 5 S2 10.54448/mdnt24112 Major approaches of inflammatory processes and peri-implant infections in the cellular and molecular scenario of mesenchymal stem cells, exosomes, and microRNAs: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/323 <p><strong>Introduction:</strong> Bone diseases are denoted by fractures, osteoporosis, and osteoarthritis that affect a large number of individuals, with a rising prevalence of osteopenia for 64.3 million American individuals and osteoporosis for 11.9 million by the year 2030. Dental implants are not free from possible complications with consequent failure, the causes of which are still the subject of debate in the dental scientific community. In particular, peri-implant infections are multifactorial pathological conditions characterized by inflammation of the peri-implant mucosa with or without progressive loss of supporting bone. Specific expression profiles of microRNAs (miRNAs) extracted from peri-implant tissues are predictive of specific clinical outcomes of dental implants and can be used as biomarkers in implant dentistry for diagnostic and prognostic purposes. <strong>Objective:</strong> It was to address the main approaches to inflammatory processes and peri-implant infections and dental implants in the cellular and molecular scenarios of mesenchymal stem cells, exosomes, and microRNAs, emphasizing the main biomarkers in the therapeutic control of harmful dental implant processes. <strong>Methods: </strong>The PRISMA Platform systematic review rules were followed. The search was carried out from October 2023 to January 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 138 articles were found, 44 articles were evaluated in full and 34 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 26 studies with a high risk of bias and 24 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X2=67.9%&gt;50%. It was concluded that specific expression profiles of miRNAs extracted from peri-implant tissues are predictive of specific clinical outcomes of dental implants and can be used as biomarkers in implant dentistry for diagnostic and prognostic purposes. Studies have shown that many of the miRNAs extracted from the implant's peri-crevicular fluid were common to those detected in soft tissues taken from the same peri-implant sites. Evidence suggests that exosomes derived from adipose-derived stem cells exhibit similar functions to those cells, with low immunogenicity and no tumorization. Insufficient bone volume directly impacts the placement of dental implants. Adipose-derived stem cells can accelerate bone healing when combined with dental implants. An increase in the concentration of exosomes with negative expression of miRNA-21-3p and miRNA-150-5p may be related to the development of peri-implantitis.</p> Danilo Martins Paladino João Antônio Figueiredo Vidoto Rafael Bertelli Lopes Fabio Alarcon Idalgo Alvaro José Cicareli Elias Naim Kassis Copyright (c) 2024 Danilo Martins Paladino, João Antônio Figueiredo Vidoto, Rafael Bertelli Lopes, Fabio Alarcon Idalgo, Alvaro José Cicareli, Elias Naim Kassis https://creativecommons.org/licenses/by/4.0 2024-03-01 2024-03-01 5 S2 10.54448/mdnt24S108 Immediate dental implants and major approaches: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/359 <p><strong>Introduction:</strong> The use of dental implants in the rehabilitation of partially or completely edentulous patients followed a protocol of submerging the implant for 3-6 months during osseointegration to reduce the risk of implant failure caused by movements at the interface. In this context, subsequent improvements in surgical techniques such as implant structure and masticatory forces have led to evidence that immediate loading procedures can be successful (immediately loaded dental implant -ILI). <strong>Objective:</strong> It was to demonstrate, through a systematic review, the main clinical approaches of immediate dental implants with other types of dental implants, presenting the indication criteria and follow-up of the procedures. <strong>Methods:</strong> The PRISMA Platform systematic review rules were followed. The search was carried out from October 2023 to January 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 133 articles were found, 45 articles were evaluated in full and 37 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 25 studies with a high risk of bias and 23 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X<sup>2</sup>=59.9%&gt;50%. It was concluded that success rates with the ILI technique are compatible with those of delayed loading, as long as certain guidelines are followed, which were divided into factors related to the patient, surgical technique, implant, prosthesis, and aesthetics. The high success rate is a consequence of correct surgical and prosthetic planning, and harmony between the implant system, patient, and dental surgeon. Regarding the region, it can currently be said that ILI in total jaw rehabilitation is a procedure with high success rates that should and can be applied in all cases in which the technique is efficient in providing adequate primary stability to the implants. Furthermore, the immediate provisional restoration did not have a significant peri-implant impact on the soft and hard tissues surrounding the immediately placed single dental implants.</p> Gabriel Nunes Gomes Priscila Karimy Nery Baraúna Alvaro José Cicareli Elias Naim Kassis Copyright (c) 2024 Gabriel Nunes Gomes, Priscila Karimy Nery Baraúna, Alvaro José Cicareli, Elias Naim Kassis https://creativecommons.org/licenses/by/4.0 2024-02-28 2024-02-28 5 S2 10.54448/mdnt24S107 Major characteristics and clinical results of the all-on-four technique in implant dentistry: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/358 <p><strong>Introduction:</strong> In the context of dental implant methods, the all-on-four technique has proven to be beneficial in reducing stress around dental implants and is a very effective treatment option for edentulous patients. <strong>Objective:</strong> A systematic review was carried out to present the main characteristics and clinical results of the all-in-four technique in implant dentistry. <strong>Methods:</strong> The PRISMA Platform systematic review rules were followed. The search was carried out from October 2023 to January 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 82 articles were found, 40 articles were evaluated in full and 22 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 12 studies with a high risk of bias and 10 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X<sup>2</sup>=55.7%&gt;50%. It was concluded that technical knowledge and anatomical understanding in all-on-four mandibular surgery are essential for predictable and consistent surgical results. The all-on-four configuration proved to be biomechanically superior to parallel implants, considering the radial stresses on the implants and cortical bone. All-on-four treatments are based on the insertion of two anterior implants and two angled ones to cover a larger area. Therefore, implant-supported prostheses may have higher success and survival rates. The cost of treatment can be reduced. Chewing stress can also be minimized to a greater extent. It was observed that the lowest stress was observed in both lateral and vertical loads in the peri-implant region</p> Caio Bronca Maranini João Pedro Andrade Freitas de Morais Souza Alvaro José Cicareli Elias Naim Kassis Copyright (c) 2024 Caio Bronca Maranini, João Pedro Andrade Freitas de Morais Souza, Alvaro José Cicareli, Elias Naim Kassis https://creativecommons.org/licenses/by/4.0 2024-02-27 2024-02-27 5 S2 10.54448/mdnt24S106 The alcohol effect on the performance of athletes of a Medical School in the Northwest of São Paulo: a cross-sectional observational study https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/357 <p><strong>Introduction:</strong> The medical schools of the São Paulo region perform sports competitions as a way of socialization and integration between them. Thus, each medical school has its training routine and focuses on performance during the year. However, these study places also have parties, which have as a characteristic the high consumption of alcoholic drinks. <strong>Objective:</strong> The present study aims to analyze the constancy of alcohol consumption by the students of a medical school in the northwest of São Paulo who practice physical exercises, as well as to evaluate the reasons and possible consequences of this substance in the organism of these academics. <strong>Methods:</strong> The research is observational and transversal, done by a virtual formulary, via "Google Forms". <strong>Results:</strong> It observed the ingest of alcohol, mostly, twice a week by 75% of the interviewed, as approximately 74% reported loss or failure in the efficiency at the next day's activities. Some of the symptoms by the majority were tiredness, sleepiness, fatigue, dehydration, and low concentration, and in the minority, cramps, spasms, and photosensitivity. Furthermore, 94% of the academics practice some exercise in their daily, third times a week. Finally, 86% of the interviewees who are competitors and ingest alcohol don’t consume it when the competition date is close. <strong>Conclusion:</strong> The medical students' routine has parties and sports, as well as the incentive for alcohol consumption. In this way, the alcohol effects, one day after ingestion, already show up and are malefic not only to the sports performance but also to the academic and personal performances. It can also be concluded that sports competitions are very important to some students since they don't consume alcoholic drinks days before the championship.</p> Isadora Gimenes Marchesan Kalina Momesso Lima Guilherme Sant’Ana Gonçalves Luana Tiemi Taniguti Ana Beatriz Bataglia Sperandio Durval Ribas Filho Tainara Costa Copyright (c) 2023 Isadora Gimenes Marchesan, Kalina Momesso Lima, Guilherme Sant’Ana Gonçalves, Luana Tiemi Taniguti, Ana Beatriz Bataglia Sperandio, Durval Ribas Filho, Tainara Costa https://creativecommons.org/licenses/by/4.0 2024-02-27 2024-02-27 5 S2 10.54448/mdnt24111 Major clinical and surgical approaches to treating orbitozygomatic and zygomatic maxillary complex fractures: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/356 <p><strong>Introduction:</strong> In the scenario of orbitozygomatic fractures, facial and head injuries account for half of deaths due to trauma, and thousands are left with long-term or permanent injuries. Fractures of the zygomatic-maxillary complex (ZMC) and zygomatic arch are common athletic injuries. Operative treatment is indicated in cases of significant displacement or functional disturbance. Technology such as virtual surgical planning, intraoperative navigation, and intraoperative imaging has the potential to improve the accuracy of treatment of challenging fractures. <strong>Objective:</strong> It was to develop a systematic review of the main clinical and surgical approaches to the treatment of orbitozygomatic and zygomatic maxillary complex fractures. <strong>Methods:</strong> The PRISMA Platform systematic review rules were followed. The search was carried out from October 2023 to January 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 102 articles were found, 26 articles were evaluated in full and 25 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 14 studies with a high risk of bias and 12 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X<sup>2</sup>=57.9%&gt;50%. A single-piece fracture of the fronto-orbito-zygomatic-maxillary bone connected to a temporoparietal bone may require additional osteotomy to achieve successful results in an acute setting. Orbital volume analysis offers a valid modality for objectively evaluating the efficiency of the management of orbitozygomatic complex fractures. The success rate of the fixation procedure at 1 point of the zygomaticomaxillary complex is high, with minimal complications. Intraoperative CT/three-dimensional imaging should be used in the treatment of ZMC fractures requiring orbital floor reconstruction, where adjacent fractures require fixation and/or when ≥ 2 axes are displaced ≥ 5 mm.</p> Priscila Karimy Nery Baraúna Gabriel Nunes Gomes Igor Mariotto Beneti Copyright (c) 2024 Priscila Karimy Nery Baraúna, Gabriel Nunes Gomes, Igor Mariotto Beneti https://creativecommons.org/licenses/by/4.0 2024-02-27 2024-02-27 5 S2 10.54448/mdnt24S105 Evidence of the relationship between periodontal diseases/caries and cardiovascular diseases: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/355 <p><strong>Introduction:</strong> Dental caries is highly prevalent worldwide and is responsible for significant morbidity. Metabolic diseases such as diabetes and obesity share several common environmental determinants with tooth decay. Cardiovascular disease is a common and complex disease, with high morbidity and mortality rates, representing a serious threat to human health. <strong>Objective:</strong> It was to develop a systematic review to present, through clinical studies and systematic reviews/meta-analyses, evidence of the relationship between periodontal diseases/cavities and cardiovascular diseases. <strong>Methods:</strong> The PRISMA Platform systematic review rules were followed. The search was carried out from November 2023 to January 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 108 articles were found, 36 articles were evaluated in full and 17 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 24 studies with a high risk of bias and 22 studies that did not meet GRADE and AMSTAR2. Most studies did not show homogeneity in their results, with X<sup>2</sup>=64.7%&lt;50%. It was concluded that dental diseases such as periodontitis and tooth decay increase the risk of cardiovascular diseases. The number of missing teeth is significantly associated with selfreported history of stroke. The bacterium <em>Streptococcus mutans</em>, harboring the Cnm gene encoding the Cnm collagen-binding protein, is associated with the development of hypertensive intracerebral hemorrhage.</p> Isabella Romero de Freitas Ana Júlia Bernardes Crepaldi João Basta Junior Andreia Borges Scriboni Copyright (c) 2024 Isabella Romero de Freitas, Ana Júlia Bernardes Crepaldi, João Basta Junior, Andreia Borges Scriboni https://creativecommons.org/licenses/by/4.0 2024-02-21 2024-02-21 5 S2 10.54448/mdnt24S104 Clinical significance of the main methods of root canal irrigation in endodontics: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/354 <p><strong>Introduction:</strong> In the context of endodontic treatments, irrigation is one of the most important aspects of the biomechanical preparation of the root canal. The arsenal of irrigation solutions designed for endodontic treatment and commercially available is broad. The choice of the correct solution depends on the combination of the properties of the solution associated with the effects to be obtained with irrigation, according to the clinical condition. <strong>Objective:</strong> It was to carry out a systematic review of the different endodontic irrigation methods, as well as to show the different clinical indications for use, comparing the effectiveness, biocompatibility, and influence on the dentin surface of irrigation solutions. <strong>Methods:</strong> The PRISMA Platform systematic review rules were followed. The search was carried out from October to December 2023 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 115 articles were found, 50 articles were evaluated in full and 41 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 10 studies with a high risk of bias and 25 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X<sup>2</sup>=57.8%&lt;50%. It was concluded that irrigation plays a fundamental role in the success of endodontic treatment. Although hypochlorite is the most important irrigating solution, no irrigant can perform all of the tasks required by irrigation. A detailed understanding of the mode of action of various solutions is important for optimal irrigation. New developments such as mechanical devices will help promote safe and effective irrigation. Within the limitations of this study, the use of the selfadjusting file system with the combination of EDTA and NaOCl improved Ca(OH)<sub>2</sub> removal. The passive ultrasonic irrigation and the self-adjusting file system were more effective in removing Ca(OH)<sub>2</sub> from the lateral grooves in the apical parts of the root canal than the EndoVac and conventional syringe irrigation systems.</p> Amanda Cristina Segala Denise Vasconcelos Tasinaffo Fábio Pereira Linhares de Castro Copyright (c) 2024 Amanda Cristina Segala, Denise Vasconcelos Tasinaffo, Fábio Pereira Linhares de Castro https://creativecommons.org/licenses/by/4.0 2024-02-17 2024-02-17 5 S2 10.54448/mdnt24S103 Major clinical outcomes of the relationship of metabolic syndrome with the success of dental implants: the systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/352 <p><strong>Introduction:</strong> Studies show that around 55% of dental implants can be affected by peri-implantitis, a chronic inflammatory process induced by bacteria, which promotes osteoclast-mediated bone resorption and inhibits bone formation, leading to progressive bone loss around the implants. implants. Current evidence points to an increased risk of developing peri-implantitis in both obesity/metabolic syndrome (MS) and diabetes mellitus (DM) conditions compared to the healthy population. <strong>Objective:</strong> It was to develop a systematic review to present the main clinical outcomes of the relationship between metabolic syndrome and the success of dental implants. <strong>Methods:</strong> The PRISMA Platform systematic review rules were followed. The search was carried out from October to December 2023 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 92 articles were found, 26 articles were evaluated in full and 19 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 14 studies with a high risk of bias and 12 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X<sup>2</sup>=53.5%&gt;50%. It was concluded that there is a correlation between the presence of metabolic syndrome and a higher prevalence of some bacterial species in the peri-implant groove, regardless of the peri-implant status. Metabolic syndrome has been shown to significantly reduce bone formation in the periimplant area in the short term. Metabolic syndrome and diabetes mellitus represent an increased risk of developing peri-implantitis. Peri-implantitis requires treatment to induce new bone formation around an implant. However, this is challenging as peri-implantitis, particularly in obese or diabetic conditions, has a microenvironment that is characterized by increased inflammation.</p> Graziele Bertoldo Lopes da Silva Hiago Silva Mendes Brasileiro Isabela Fernanda Furlan Alvaro José Cicareli Fabio Alarcon Idalgo Copyright (c) 2024 Graziele Bertoldo Lopes da Silva, Hiago Silva Mendes Brasileiro, Isabela Fernanda Furlan, Alvaro José Cicareli, Fabio Alarcon Idalgo https://creativecommons.org/licenses/by/4.0 2024-02-09 2024-02-09 5 S2 10.54448/mdnt24S102 Major clinical outcomes of the use of biostimulators (L-PRF and coenzyme Q10) in the optimization of buccomaxillofacial surgery: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/351 <p><strong>Introduction:</strong> Tissue engineering combines three key elements matrix (three-dimensional structures that support growth, collagen cell, bone mineral), signaling molecules (growth factors (GF) and leukocyte cytokines), and cells (osteoblasts, fibroblasts or other adequate populations for tissue regeneration. Many studies suggest that antioxidants act as inhibitors of osteoclastogenesis and the inhibitory effect of CoQ10 on osteoclast differentiation. These findings highlight the potential therapeutic applications of CoQ10 for the treatment of bone diseases. <strong>Objective:</strong> The present study highlighted the main approaches to the use of fibrin-rich plasma (L-PRF) and coenzyme Q10 in buccomaxillofacial surgery through a systematic review. <strong>Methods:</strong> The systematic review rules of the PRISMA Platform were followed. The search was carried out from October 2023 to January 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, using articles from 2006 to 2022. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed accordingly, according to the Cochrane instrument.<strong> Results and Conclusion: </strong>A total of 104 articles were found, 38 articles were evaluated and 23 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 36 studies with a high risk of bias and 20 studies that did not meet GRADE. The use of platelet and leukocyte-rich fibrin can reduce bone absorption, infection, pain, local edema, and wound healing. L-PRF presents itself as an autogenous biomaterial with great versatility, low cost, easy acquisition and wide use, and infinite possibilities. It can be combined with other materials in the most diverse areas of dentistry. Also, CoQ10 concentrations can suppress ROS, which is needed as a signaling intermediate. CoQ10 acts as an enhancer of all stages of osteoblastic differentiation. Thus, CoQ10 suppresses osteoclast differentiation by eliminating generated intracellular ROS. Furthermore, CoQ10 enhances bone regeneration in all differentiation processes through transcription factor activity.</p> Patricia Consuelo Nacimba Medina Brian Steven López Igor Mariotto Beneti Copyright (c) 2023 Patricia Consuelo Nacimba Medina, Brian Steven López, Igor Mariotto Beneti https://creativecommons.org/licenses/by/4.0 2024-02-07 2024-02-07 5 S2 10.54448/mdnt24110 Enucleation of a solitary pancreatic tail insulinoma: a case report and review of the literature https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/350 <p><strong>Introduction:</strong> Insulinomas are the most common pancreatic neuroendocrine tumors. They secrete insulin and result in endogenous hyperinsulinaemic hypoglycemia. The diagnosis of insulinoma was classically based on the fulfillment of Whipple’s triad; hypoglycaemia (plasma glucose &lt;50mg/dL), neuroglycopaenic symptoms, and the prompt relief of such symptoms with the administration of glucose. Preoperative localization of the insulinoma will help to plan the type of surgery necessary, either enucleation or pancreatic resection, and also decide on the approach, either open or laparoscopic. <strong>Case description:</strong> A 53-year-old farmer presented with neuroglycopenia symptoms with biochemical evidence of endogenous hyperinsulinaemic hypoglycemia during the mixed meal test. Imaging evidence in the form of CT and MRI showed a benign, approximately 1cm, solitary pancreatic tail insulinoma. Intraoperative ultrasonography confirmed the findings and the patient underwent enucleation of the tumor. Histology revealed a grade 2 pancreatic neuroendocrine tumor with confirmation of an insulinoma on immunohistochemistry. <strong>Conclusion:</strong> Pancreatic insulinomas, a rare pancreatic tumor, the commonest of the pNET present with neuroglycopenia. Diagnosis entails biochemical confirmation of endogenous hyperinsulinaemic hypoglycemia on a 72-hour prolonged fasting test. Noninvasive imaging in the form of CT as the first line, followed by MRI is used for localization and assessment of resectability. EUS and ASVS are additional invasive imaging in diagnostic difficulty. Enucleation and intraoperative ultrasonography is the treatment of choice for small, benign, pancreatic insulinomas.</p> Deshan Mario Gomez Duminda Subasinghe Copyright (c) 2024 Deshan Mario Gomez, Duminda Subasinghe https://creativecommons.org/licenses/by/4.0 2024-03-08 2024-03-08 5 S2 10.54448/mdnt24202 Major microRNAs and regulation of gut microbiota in patients with obesity: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/349 <p><strong>Introduction:</strong> Obesity represents a pandemic represented as a chronic, long-term imbalance between calorie intake and energy expenditure. MicroRNAs (miRNAs) stand out. They are a class of small non-coding RNAs that regulate gene expression, and changes in their expression and functions have been associated with many diseases, including metabolic disorders and obesity. <strong>Objective:</strong> It was to present the main considerations and results of clinical studies on the relationship between obesity, gut microbiota, and microRNAs in inflammatory and immunological processes through a systematic review. <strong>Methods:</strong> The PRISMA Platform systematic review rules were followed. The search was carried out from August to September 2023 in the Web of Science, Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 121 articles were found, and 44 articles were evaluated in full and 30 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 22 studies with a high risk of bias and 21 studies that did not meet GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X<sup>2</sup>=77.5%&gt;50%. It was concluded that microRNAs regulate gene expression in adipose tissue, impact the regulation of metabolism and energy homeostasis, and regulate adipogenesis signaling pathways in white, beige, and brown adipose tissue. For example, microRNA (miR-143) promotes brown adipose tissue thermogenesis and inhibits white adipose tissue adipogenesis. Some miRNAs have been implicated in the control of body weight gain, glucose homeostasis, insulin resistance, and lipid metabolism, with crosstalk with the gut microbiota. Furthermore, an association was found between <em>B. eggerthi</em> abundance, miR-183-5p expression, and adiponectin levels. Expression of miR-15a-5p was found to be associated with <em>H. parainfluenzae</em> abundance and insulin levels.</p> Renan Francisco Merloto Bruna Rocha Soares Copyright (c) 2023 Renan Francisco Merloto, Bruna Rocha Soares https://creativecommons.org/licenses/by/4.0 2024-01-27 2024-01-27 5 S2 10.54448/mdnt24109 Prevalence and associated factors of substance use disorders among people who use drugs: a population-based cross-sectional study in the Western Province of Sri Lanka https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/348 <p><strong>Introduction:</strong> This study aimed to assess the prevalence of substance use disorders and associated factors among people who use drugs in the Western Province of Sri Lanka. <strong>Methods: </strong>A cross-sectional study was conducted in the Western Province of Sri Lanka, using a respondent-driven sampling technique. Sampling was initiated with 20 seeds and peers were recruited by peers through handing out coupons. The number of recruited participants was proportional to the estimated number of people who use drugs in each district of Western Province. A total of 870 people who use drugs participated in the study. A validated Sinhala version of the Drug Abuse Screening Test was used to assess the drug use severity among the participants and a pre-tested validated questionnaire was used to collect data to assess the associated factors. RDS Analyst software version 0.64 was used to assess frequency estimates. To assess factors associated with substance use disorders multiple logistic regression analysis was performed using SPSS software version 22. <strong>Results: </strong>The median age of the study sample was 39 years. The incidence of substance use disorder among the sample was 88.4%. Being employed, using heroin as a psychoactive drug, using drugs daily, using more than one drug, being a heavy alcohol user, buying drugs, stealing money or exchanging goods to get drugs, spending a substantial amount per month on drugs (Rs &gt; 40,001), past or present medical history of tuberculosis and those who had disclosed their drug use behavior to their immediate family were found to be significantly associated with an increased risk of having a substance use disorder.<strong> Conclusion: </strong>A high prevalence of substance use disorder was found in the sample with multiple economic, behavioral, and health-related risk factors.</p> Sashiprabha Dulanjalee Nawaratne Janaki Vidanapathirana Copyright (c) 2024 Sashiprabha Dulanjalee Nawaratne, Janaki Vidanapathirana https://creativecommons.org/licenses/by/4.0 2024-03-20 2024-03-20 5 S2 10.54448/mdnt24203 Relationship between bruxism and orofacial dysfunction and psychosocial problems developed by the SARS-CoV-2 pandemic: a literature review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/347 <p><span class="fontstyle0">In 2019, the world was struck by a viral pathology that affected not only people's physiological health but their mental health. The coronavirus directly affects the respiratory system of an infected individual, causing serious breathing problems that have led to many deaths. However, not only respiratory complications were a consequence of COVID-19, but the development of psychological illnesses was quite common, a result of the drastic change in life that people had to go through and face the fear of uncertainty. This directly affected people's oral health, causing problems such as temporomandibular disorders (TMD) and bruxism to occur more frequently in people. This work aims to carry out a literature review, of articles taken from online databases, such as PubMed, Scielo, and Google Academic, to analyze the increase in cases of occlusion problems generated in the pandemic as a result of stress, anxiety, and depression. developed by people during the pandemic, in addition to showing diagnosis and treatment carried out by dental surgeons on the front line of contamination (the oral cavity).</span> </p> Ana Beatriz Gonçales Mariana de Paula Oliveira Laura Cesaretto Carlos Alberto Costa Neves Buchala Copyright (c) 2024 Ana Beatriz Gonçales, Mariana de Paula Oliveira, Laura Cesaretto, Carlos Alberto Costa Neves Buchala https://creativecommons.org/licenses/by/4.0 2024-01-23 2024-01-23 5 S2 10.54448/mdnt24S101 Maxillary sinus surgery and use of fibrin-rich plasma: a systematic review https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/346 <p><strong>Introduction:</strong> In around 25% of all maxillary sinuses, there is an accessory bone that is located in a lower portion than the main ostium, and all the mucus produced and the particles trapped in this mucus are directed through the ciliary beat to the ostium. When a dental element is lost in the posterior region of the maxilla, there is natural reabsorption of the alveolar process and at the same time, pneumatization of the maxillary sinus occurs. <strong>Objective:</strong> It was to carry out a systematic review to elucidate the main clinical approaches to the use of fibrin-rich plasma in the bone regeneration process in maxillary sinus surgeries. <strong>Methods: </strong>The PRISMA Platform systematic review rules were followed. The search was carried out from October to December 2023 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. <strong>Results and Conclusion:</strong> A total of 115 articles were found, 40 articles were evaluated in full and 25 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 20 studies with a high risk of bias and 25 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X<sup>2</sup>=55.5%&lt;50%. It was concluded that to improve osseointegration and bone anchorage, surface modifications can be chemical, such as calcium phosphate (Ca-P), or physical impregnation, being related to the microtopography of the implant. Several variables affect the biological activity of FRP preparations, such as the number of centrifuges used, centrifugation speed, and other protocols that result in preparations with various volumes, platelet numbers, amount of growth factors, and concentration of fundamental white blood cells and erythrocytes. Some researchers recommend avoiding tissue exposure to FRP-containing leukocytes, arguing that an inflammatory reaction may occur. On the other hand, other authors have described beneficial effects due to increased immunological and antibacterial resistance, although there is no clinical evidence to support its effect. FRP has gained prominence in the scientific community because it does not require the addition of an activator or anticoagulant, making the product more autologous, and featuring a fibrin network that protects growth factors, keeping them in place for longer.</p> Talysson Silva de Oliveira Morais Abner da Rocha Cardoso Costa Fabio Alarcon Idalgo Alvaro José Cicareli Copyright (c) 2023 Talysson Silva de Oliveira Morais, Abner da Rocha Cardoso Costa, Fabio Alarcon Idalgo, Alvaro José Cicareli https://creativecommons.org/licenses/by/4.0 2024-01-11 2024-01-11 5 S2 10.54448/mdnt24108