Abstract
Introduction: Over the past 30 years, the number of dental implant procedures has grown significantly worldwide, reaching approximately 1 million per year. In Brazil, implantology has evolved very rapidly in recent decades, with high success rates. Various materials can be used as bone grafts, each with different properties, such as those related to neovascularization. Guided bone regeneration promotes the formation of new bone tissue. When grafting procedures are necessary, the focus is often on the type of biomaterial to be used and the success and predictability of the results. Objective: This study aimed to conduct a concise systematic review of bone regeneration processes using biomaterials and the main molecular and cellular constituents for implantology. Methods: The research was conducted from January to February 2026 in the Scopus, PubMed, Science Direct, and SciELO databases, using older scientific articles considered gold standard references up to 2026. The quality of the studies was based on the GRADE instrument, and the risk of bias was assessed using the Cochrane instrument. Results and Conclusion: 158 studies were found and submitted to eligibility analysis. The final sample presented 22 eligible studies, which were described in the systematic review. Most studies showed homogeneity in their results, with X² = 68.8% > 50%. Due to bone regeneration and biological barriers in graft surgeries, there has been technological growth in these materials, as they are seen as potential tools for treating bone loss. The greater potential of guided bone regeneration was associated with graft material due to the higher degree of vital bone and the lower percentage of residual graft particles. All bone substitute materials studied resulted in efficient bone formation for dental implants and alveolar ridge preservation procedures.