Abstract
Macrophages are specialized cells, originated from blood monocyte, differentiate in tissues, and involved in the destruction of foreign pathogens. They also can release cytokines and activate other cells and initiate inflammation. Macrophage polarization from M1 type to M2 –type has been found to be related to various diseases including cancer, diabetes, coronary artery diseases (CAD), etc. Here we did a brief review to convince that regular light to intense type physical exercise can induce polarization of macrophage from its one form (M1) to the other form (M2), and can improve the various disease conditions. The cellular as well as the molecular events that are found with the physical exercise (PE) indicate that the PE could be a non-pharmacological management for various diseases with minimal side effects.