Abstract
Introduction: The production or regeneration of any tissue is a complex biological process in itself, since it requires intrinsically regulated interactions between cells, the action of systemic hormones, the participation of extracellular matrix components, and the local action of so-called growth factors. Objective: It was to review the concepts related to growth factors, as well as in relation to platelet rich plasma and bone morphogenetic protein as an adjuvant in bone regeneration therapies directed to implant dentistry. Methods: The systematic review rules of the PRISMA Platform were followed. The search was conducted from January to March 2026 across the Embase, Scopus, PubMed, Web of Science, and Google Scholar databases. The quality of the studies was assessed using the GRADE instrument, and the risk of bias was evaluated according to the Cochrane instrument. Results and Conclusion: According to the GRADE instrument, most studies presented homogeneous results, with X2=81.7% > 50%. A total of 134 articles were found and submitted for eligibility analysis, with 45 final studies selected to compose the results of this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 14 studies with a high risk of bias and 22 studies that did not meet GRADE and AMSTAR-2 standards. It was concluded that the greatest advantages of the use of platelet-rich plasma are its ability to accelerate the process of bone regeneration by increasing the number of growth factors present in human platelets. On the other hand, it is observed that one of its major disadvantages is the low life expectancy of these platelets in the recipient or graft bed. However, it is also known that the PRP technique would only accelerate a process of bone regeneration that normally already occurs, and this process follows its path until the formation of mature bone.