Abstract
Introduction: According to the World Dental Federation, the hypothesis that more than 90.0% of the world population will have any oral disease in their lifetime. The discovery of an immunoenzymatic mucosal defense system, coupled with the advances of immunology, demonstrate the need to know their concepts and their possible interrelations with the installation and progression of the cariogenic process. Objective: Therefore, the present work carried out a literature review to verify the main approaches regarding the influence of the immune system on caries disease. Methods: Experimental and clinical studies were included (case reports, retrospective, prospective and randomized trials) with qualitative and/or quantitative analysis. Initially, the keywords were determined by searching the DeCS tool (Descriptors in Health Sciences, BIREME base) and later verified and validated by MeSh system (Medical Subject Headings, the US National Library of Medicine). Series of Articles And Eligibility: A total of 27 articles were found involving. Initially, it was held the exclusion existing title and duplications in accordance with the interest described this work. After this process, the summaries were evaluated and a new exclusion was held. A total of 22 articles were evaluated in full, and 18 were included and discussed in this study. Conclusion: There are an important network and cascade of defense events between immunological processes and caries disease. Thus, it is necessary to have a healthy immune response to reduce the incidence of caries.