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Review
Published: 03-07-2025

Major evidence from the crosstalk between nutrology and lifestyle for healthy longevity: a systematic review

Ceri Clinic, Imperatriz, Maranhão, Brazil
University Center of Patos de Minas, nephrology, Minas Gerais, Brazil
Pouso Alegre Medical Center, Minas Gerais, Brazil
Women's Medicine Clinic. Gynecology. Unimed Volta Redonda Hospital, Rio de Janeiro, Brazil
Toledo Medical Clinic, Florianópolis, Santa Catarina, Brazil
Acre State Hospital Foundation, nephrology, Acre, Brazil
USF MIMOSO 1 - Luis Eduardo Magalhães, Bahia, Brazil
UFG - Federal University of Goiás, Goiás, Brazil
CLIAGO Clinic, gynecology, Rio Branco, Acre, Brazil
IESS - Institute for Healthy Weight Loss of Sorriso. Av. João Batista Francio, Recanto dos Pássaros, Mato Grosso, Brazil
Nutrology Lifestyle Healthy longevity Healthy aging

Abstract

Introduction: Life expectancy worldwide has increased significantly. Centenarians represent a successful aging phenomenon. Genetic, environmental, and lifestyle factors can determine the life expectancy of humans. Certain healthy foods are associated with longer telomere lengths. Objective: It was to present the main evidence of the crosstalk between nutrition, lifestyle, and healthy longevity to promote health and improve quality of life in aging. Methods: The PRISMA Platform systematic review rules were followed. The research was carried out from May to July 2024 in the Web of Science, Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: 133 articles were found. A total of 33 articles were evaluated in full and 31 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 27 studies with a high risk of bias and 23 studies that did not meet GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X2=72.5%>50%. It was concluded that many metabolic or chronic diseases have been implicated in poor diet and lifestyle. Improving diet quality is associated with reduced all-cause mortality, considering that multivitamin and multimineral supplements can improve life expectancy, such as nutrients such as melatonin and coenzyme Q10 and micronutrients. The synergistic relationship of nutrients to influence physiological and cognitive function. Low concentrations of vitamin D have been linked to accelerated decline in cognition across ethnicities. N-acetylcysteine can help treat schizophrenia, bipolar disorder, and depression by decreasing oxidative stress and reducing glutamatergic dysfunction, and has broader preclinical effects on mitochondria, apoptosis, neurogenesis, and telomere lengthening. A healthy (low-sugar) plant-based diet with a reduced intake of energy-dense meat and processed meat enables healthy longevity. Several mechanisms are involved in the aging process, highlighting AMPK (AMP-activated protein kinase), SIRT1 (sirtuin), mTOR (mammalian target of rapamycin), and insulin/IGF-1 (insulin-like growth factor-1), autophagy impaired, changes in epigenetics, chronic low-grade inflammation, and cellular changes, senescence (inflammation), oxidative stress and telomere shortening.

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How to Cite

Ariadne Fonseca Carvalho, Ramos, K. A., Telles, C. R. e L., Ferreira, M. A. O. de M., Rocha, . P. M. M., Oliveira, L. P. de, Ricardi, G., Silva Junior, A. C. da, Teixeira, T. A. B. V., & Moreira, E. V. F. (2025). Major evidence from the crosstalk between nutrology and lifestyle for healthy longevity: a systematic review. MedNEXT Journal of Medical and Health Sciences, 6(S2). https://doi.org/10.54448/mdnt25S201