Abstract
Introduction: Dental caries is highly prevalent worldwide and is responsible for significant morbidity. Metabolic diseases such as diabetes and obesity share several common environmental determinants with tooth decay. Cardiovascular disease is a common and complex disease, with high morbidity and mortality rates, representing a serious threat to human health. Objective: It was to develop a systematic review to present, through clinical studies and systematic reviews/meta-analyses, evidence of the relationship between periodontal diseases/cavities and cardiovascular diseases. Methods: The PRISMA Platform systematic review rules were followed. The search was carried out from November 2023 to January 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 108 articles were found, 36 articles were evaluated in full and 17 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 24 studies with a high risk of bias and 22 studies that did not meet GRADE and AMSTAR2. Most studies did not show homogeneity in their results, with X2=64.7%<50%. It was concluded that dental diseases such as periodontitis and tooth decay increase the risk of cardiovascular diseases. The number of missing teeth is significantly associated with selfreported history of stroke. The bacterium Streptococcus mutans, harboring the Cnm gene encoding the Cnm collagen-binding protein, is associated with the development of hypertensive intracerebral hemorrhage.