Nowadays, a harmonious smile depends on several factors ranging from the aesthetic to the functional, but it is known that a smile opens doors and is also known as a business card for anyone. The present study aims to discuss the issue of orofacial harmonization nowadays, the existing indications, and the contraindications of this treatment modality, through a literature review. This study is a systematic literature review and for its realization, a bibliographical survey of articles in the main internet databases was carried out. It is worth remembering that, like any procedure, it is necessary to carry out an evaluation, to plan well how the procedure will be carried out, to know the indications, the contraindications, the places that can be applied, the way to dilute the product, when using botulinum toxin. However, this study made it possible to understand that orofacial harmonization, in addition to being an aesthetic procedure, has characteristics that are linked to the question of the biomechanics of the smile, forgetting the question of the person's self-esteem.