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MedNext Journal of Medical and Health Sciences
Review
DOI: 10.54448/mdnt23218
Submitted: 06-08-2023
Published: 06-08-2023

Clinical evidence of bio-stimulators for cervicofacial liposculpture: a systematic review

UNIOFTAL- Ophthalmology And Eye Plastic, São José do Rio Preto, São Paulo, Brazil
UNIOFTAL- Ophthalmology And Eye Plastic, São José do Rio Preto, São Paulo, Brazil / PERUSSI OPHTHALMOLOGY, Guarujá, São Paulo, Brazil / PERUSSI OPHTHALMOLOGY, São Vicente, São Paulo, Brazil
FACERES – Faculty of Medicine of Sao Jose do Rio Preto, Sao Paulo, Brazil / ABRAN - Associação Brasileira de Nutrologia/Brazilian Association of Nutrology, Catanduva, Sao Paulo, Brazil
Facial liposculpture Vascular stromal fraction Mesenchymal stem cells Platelet-rich plasma Exosomes MicroRNA

Abstract

Introduction: In the liposculpture scenario, and at the cellular and molecular level, tissue engineering has numerous advantages that meet the needs of the injured tissue or organ for the regeneration process or fillings and contours. Biological microenvironments enable cell recognition and signaling cascades for neovascularization and stabilization of fat grafting. Objective: A concise systematic review was carried out on the use of potential biostimulators (cells and molecules) and the biochemical and physiological mechanisms that can contribute to the successful process of cervicofacial liposculpture, to promote neovascularization and stabilization of fat grafting or fat reduction. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from February to April 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 96 articles were found. A total of 36 articles were fully evaluated and 34 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 11 studies at high risk of bias and 37 studies that did not meet the GRADE. The present study showed that the use of potential bio stimulators such as stromal vascular fraction cells and mesenchymal stem cells from adipose tissue, exosomes, microRNA, and PRP, as well as the molecules secreted by these cells, can contribute to the successful process of cervicofacial liposculpture, to promote neovascularization and stabilization of fat grafting or fat reduction. Furthermore, studies have shown that the use of adipose tissue plus PRP led to the presence of more pronounced inflammatory infiltrates and greater vascular reactivity, increased vascular permeability, and certain reactivity of the nervous component, noting that the addition of 20% PRP activated with calcium to adipose tissue grafts can enhance the results of regenerative and aesthetic facial surgeries.

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How to Cite

Liedtke, F. S., Garcia, A. P., & Zotarelli Filho, I. J. (2023). Clinical evidence of bio-stimulators for cervicofacial liposculpture: a systematic review. MedNEXT Journal of Medical and Health Sciences, 4(2). https://doi.org/10.54448/mdnt23218