Skip to main content Skip to main navigation menu Skip to site footer
MedNext Journal of Medical and Health Sciences
Review
DOI: 10.54448/mdnt23S101
Submitted: 02-01-2023
Published: 02-01-2023

Major clinical outcomes of cellular and molecular regulation in maxillofacial bone regeneration: a systematic review

UNORTE - University Center of Northern São Paulo, Dentistry department, São José do Rio Preto, São Paulo, Brazil / UNIPOS - Post graduate and continuing education, Dentistry department, São José do Rio Preto, São Paulo, Brazil
UNORTE - University Center of Northern São Paulo, Dentistry department, São José do Rio Preto, São Paulo, Brazil / UNIPOS - Post graduate and continuing education, Dentistry department, São José do Rio Preto, São Paulo, Brazil
UNORTE - University Center of Northern São Paulo, Dentistry department, São José do Rio Preto, São Paulo, Brazil / UNIPOS - Post graduate and continuing education, Dentistry department, São José do Rio Preto, São Paulo, Brazil
UNORTE - University Center of Northern São Paulo, Dentistry department, São José do Rio Preto, São Paulo, Brazil / UNIPOS - Post graduate and continuing education, Dentistry department, São José do Rio Preto, São Paulo, Brazil
UNORTE - University Center of Northern São Paulo, Dentistry department, São José do Rio Preto, São Paulo, Brazil / UNIPOS - Post graduate and continuing education, Dentistry department, São José do Rio Preto, São Paulo, Brazil
UNORTE - University Center of Northern São Paulo, Dentistry department, São José do Rio Preto, São Paulo, Brazil / UNIPOS - Post graduate and continuing education, Dentistry department, São José do Rio Preto, São Paulo, Brazil
UNORTE - University Center of Northern São Paulo, Dentistry department, São José do Rio Preto, São Paulo, Brazil / UNIPOS - Post graduate and continuing education, Dentistry department, São José do Rio Preto, São Paulo, Brazil
UNORTE - University Center of Northern São Paulo, Dentistry department, São José do Rio Preto, São Paulo, Brazil / UNIPOS - Post graduate and continuing education, Dentistry department, São José do Rio Preto, São Paulo, Brazil
Maxillofacial surgery Cell regulation Bone regeneration Biomaterials

Abstract

Introduction: The importance of knowing the constitution of this epithelium is because these hair cells play a fundamental role in the physiology of the maxillary sinus. When a dental element is lost in the posterior region of the maxilla, there is natural reabsorption of the alveolar process and, at the same time, pneumatization of the maxillary sinus will occur. Objective: It was to demonstrate, through a systematic review, the main clinical outcomes of cellular and molecular regulation in maxillofacial bone regeneration. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from September to October 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. A total of 110 articles were found, 41 articles were evaluated and 31 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 31 studies at high risk of bias and 25 studies that did not meet the GRADE. Most studies showed homogeneity in their results, with I2 =98.9% >50%. Results and Conclusion: It was found that the search for a solution to large bone defects guided the studies for regeneration therapy tissue or bone regeneration. These studies can promote the use of fillers and epithelial barriers that help in the treatment as an adjuvant to bone graft techniques, favoring greater predictability in alveolar and peri-implant reconstructions and with a good prognosis. The main filler biomaterials can be fibrin-rich plasma (FRP), Bio-Oss®. It is necessary to understand the chemical, physical and biological processes of both the biological material and the biological niche of the host. Crossing compatible information between microenvironments allows cell recognition and signaling cascades for neovascularization and regeneration and bone filling.

Metrics

Metrics Loading ...

References

  1. Iwanaga J, Matsushita Y, Watanabe K, Kageyama I, Tubbs RS, Ibaragi S. Clinical Anatomy Research Association in Oral and Maxillofacial Surgery. J Craniofac Surg. 2022 May 1;33(3):942-944. doi: 10.1097/SCS.0000000000008053.
  2. Balaji SM. Three-Dimensional Planning in Maxillofacial Surgery. Ann Maxillofac Surg. 2022 Jan-Jun;12(1):1. doi: 10.4103/ams.ams_154_22.
  3. Satishchandran S, Horan C, Roser S. Changing Dynamics of Accreditation in Oral and Maxillofacial Surgery. Oral Maxillofac Surg Clin North Am. 2022 Oct 9:S1042-3699(22)00014-0. doi: 10.1016/j.coms.2022.03.003.
  4. Zhuang G, Mao J, Yang G, Wang H. Influence of different incision designs on bone increment of guided bone regeneration (Bio-Gide collagen membrane +BioOSS bone powder) during the same period of maxillary anterior tooth implantation. Bioengineered. 2021 Dec;12(1):2155-2163. doi: 10.1080/21655979.2021.1932209. PMID: 34057023.
  5. Abdel-Kader MA, Abdelazeem AF, Ahmed NEB, Khalil YM, Mostafa MI. Oral rehabilitation of a case with regional odontodysplasia using a regenerative approach-A case report and a review of literature. Spec Care Dentist. 2019, May;39(3):330-339. doi: 10.1111/scd.12378. Epub 2019 Apr 16.
  6. Arab H, Shiezadeh F, Moeintaghavi A, Anbiaei N, Mohamadi S. Comparison of Two Regenerative Surgical Treatments for Peri-Implantitis Defect using Natix Alone or in Combination with Bio-Oss and Collagen Membrane. J Long Term Eff Med Implants. 2016;26(3):199-204. doi: 10.1615/JLongTermEffMedImplants.2016016396
  7. Chiapasco M., Casentini P., Zaniboni M. Bone augmentation procedures in implant dentistry. Int J Oral Maxillofac Implants. 2009;24 Suppl: 237-59.
  8. Choukroun J, Diss A., Simonpieri A, Girard M.O. Schhoffler C., Dohan S.L., et al.Platelet-rich-fibrin (PRF): a second generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod 2006: 101 (3): e 56 – 60.
  9. Diana C, Mohanty S, Chaudhary Z, Kumari S, Dabas J, Bodh R. Does plateletrich fibrin have a role in osseointegration of immediate implants? A randomized, single-blind, controlled clinical trial. Int J Oral Maxillofac Surg. 2018 Sep;47(9):1178-1188. doi: 10.1016/j.ijom.2018.01.001. Epub 2018 May 7.
  10. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJJ, Mouhyi J, et al. Plateletrich-fibrin (PRF); A second generation concentrate. Part I: Tecnological concepts and evolution. Oral Sugery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. 2006; 101 (3): e 37- e 44.
  11. Nícoli LG, Pigossi SC, Araújo RFdSB, Marcantonio C, Marcantonio E, Marcantonio JRE. Multidisciplinary approach to oral rehabilitation with dental implants after gunshot injury. A clinical report. The Journal of Prothestic Dentistry. 2018; 119 (3): 329 – 33.
  12. Jeong SM, Lee CU, Son JS, Oh JH, Fang Y, Choi BH. Simultaneous sinus lift and implantation using platelet-rich-fibrin as sole grafting material. J. Craniomaxillofac Surgery. 2014; 42 (6): 990 – 4.
  13. Tajima N, Ohba S, Sawase T, Asahima I. Evaluation of sinus floor augmentation with simultaneous implant placement using platelet-rich-fibrin as sole grafting material. Int J Oral Maxillofac Implants 2013;28(1):77- 83.
  14. Xuan F, Lee CU, Son JS, Jeong SM, Choi BH. A comparative study of the regenerative effect of sinus bone grafting with platelet-rich fibrin-mixed BioOss® and commercial fibrin-mixed Bio-Oss®: an experimental study. J Craniomaxillofac Surg. 2014 Jun;42(4):e47-50 [doi: 10.1016/j.jcms.2013.05.029. Epub 2013 Aug 2].
  15. Moreira AC, Silva JR, Samico RP, Nishioka GNM, Nishioka RS. Application of Bio-Oss in tissue regenerative treatment prior to implant installation: literature review. Braz Dent Sci. 22(2), 2019.
  16. Li P, Zhu H, Huang D. Autogenous DDM versus Bio-Oss granules in GBR for immediate implantation in periodontal postextraction sites: A prospective clinical study. Clin Implant Dent Relat Res. 2018 Dec;20(6):923-928. doi: 10.1111/cid.12667. Epub 2018 Sep 19.
  17. Costa JBZ, Silva F, Dultra CA, Souza LF, Santos MCNE. Uso de membranas biológicas para regeneração óssea guiada em implantodontia – uma revisão de literatura - Revista Bahiana de Odontologia. 2016 Mar;7(1):14-21.
  18. Saghiri MA, Asatourian A, Garcia-Godoy F, Sheibani N. The role of angiogenesis in implant dentistry part II: The effect of bone-grafting and barrier membrane materials on angiogenesis. Med Oral Patol Oral Cir Bucal (2016), [doi:10.4317/medoral.21200].
  19. Mesimäki K, Lindroos B, Törnwall J, Mauno J, Lindqvist C, Kontio R, Miettinen S, Suuronen R: Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. Int J Oral Maxillofac Surg 2009, 38 : 201-209.
  20. Zotarelli Filho IJ, Frascino LF, Greco OT, Araujo JDD, Bilaqui A, Kassis EN, Ardito RV and Bonilla-Rodriguez GO. Chitosan-collagen scaffolds can regulate the biological activities of adipose mesenchymal stem cells for tissue engineering. J Regen Med Tissue Eng. 2013; 2:12. http://dx.doi.org/10.7243/2050-1218-2-12.
  21. Egido-Moreno S, Valls-Roca-Umbert J, Céspedes-Sánchez JM, López-López J, Velasco-Ortega E. Clinical Efficacy of Mesenchymal Stem Cells in Bone Regeneration in Oral Implantology. Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2021 Jan 21;18(3):894. doi: 10.3390/ijerph18030894. PMID: 33494139; PMCID: PMC7908266.
  22. You JS, Kim SG, Oh, J.S., Kim, J.S. Effects of Platelet-Derived Material (PlateletRich Fibrin) on Bone Regeneration. Implant Dent. 2019 Mar 8 [doi: 10.1097/ID.0000000000000877. Epub ahead of print].
  23. Starch-Jensen T, Aludden H, Hallman M, Dahlin C, Christensen AE, Mordenfeld A. A systematic review and meta-analysis of long-term studies (five or more years) assessing maxillary sinus floor augmentation. Int J Oral Maxillofac Surg. 2018 Jan;47(1):103-116. doi: 10.1016/j.ijom.2017.05.001. Epub 2017 May 22.
  24. Strauss FJ, Stähli A, Gruber R. The use of platelet-rich fibrin to enhance the outcomes of implant therapy: A systematic review. Clin Oral Implants Res. 2018 Oct;29 Suppl 18:6-19. doi: 10.1111/clr.13275.
  25. Wu IH, Bakhshalian N, Galaustian R, Naini RB, Min S, Freire M, Zadeh HH. Retrospective Analysis of the Outcome of Ridge Preservation with Anorganic Bovine Bone Mineral: Marginal Bone Level at Implants Placed Following Healing of Grafted Extraction Sockets. Int J Periodontics Restorative Dent. 2019 Jan/Feb;39(1):131-140. doi: 10.11607/prd.3308.
  26. Zhang Y, Tangl S, Huber CD, Lin Y, Qiu L, Raush-Fan X. Effects of Choukroun’s platelet-rich-fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: a histological and histomorphometric study. J Craniomaxillofac Surg. 2012; 40 (4): 321 -8.
  27. Zhou, J., Li, X., Sun, X., Qi, M., Chi, M., Yin, L., Zhou, Y. Bone regeneration around immediate placed implant of molar teeth with autologous platelet-rich fibrin: Two case reports. Medicine (Baltimore). 2018 Nov;97(44):e13058. doi: 10.1097/MD.0000000000013058.
  28. Momen-Heravi F, Peters SM, Garfinkle L, Kang P. Acellular Dermal Matrix as a Barrier for Guided Bone Regeneration of Dehiscence Defects Around Dental Implants: A Clinical and Histological Report. Implant Dent. 2018 Aug;27(4):521-524 [doi: 10.1097/ID.0000000000000796].
  29. Nizam N, Eren G, Akcali A, Donos N. Maxillary sinus augmentation with leukocyte and platelet-rich fibrin and deproteinized bovine bone mineral: A splitmouth histological and histomorphometric study. Clin Oral Implants Res. 2018 Jan;29(1):67-75 [doi: 10.1111/clr.13044.
  30. Pichotano EC, De Molon RS, Freitas De Paula LG, De Souza RV, Marcantonio E JR, Zandim-Barcelos DL. Early Placement of Dental Implants in Maxillary Sinus Grafted With Leukocyte and Platelet-Rich Fibrin and Deproteinized Bovine Bone Mineral. J Oral Implantol. 2018 Jun;44(3):199-206. doi: 10.1563/aaid-joi-D-17-00220.
  31. Tatullo M, Marrelli M, Cassetta M, Pacifici A, Stefanelli LV, Scacco S, Dipalma G, Pacifici L, Inchingolo F. Platelet Rich Fibrin (P.R.F.) in reconstructive surgery of atrophied maxillary bones: clinical and histological evaluations. Int J Med Sci. 2012;9(10):872-80 [doi: 10.7150/ijms.5119.

How to Cite

Anjos, B. M. V. dos, Alves, L. G., Idalgo, F. A., Pereira, S. A. dos S., Nunes, A. G., Kassis, E. N., Cicareli, A. J., & Beneti, I. M. (2023). Major clinical outcomes of cellular and molecular regulation in maxillofacial bone regeneration: a systematic review. MedNEXT Journal of Medical and Health Sciences, 4(1). https://doi.org/10.54448/mdnt23S101