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MedNext Journal of Medical and Health Sciences
Review
DOI: 10.54448/mdnt22S603
Submitted: 30-09-2022
Published: 30-09-2022

Incidence and major clinical approaches of aneurismatic bone cysts: a concise systematic review

UNORTE - University Center of Northern São Paulo, Dentistry department, São José do Rio Preto, São Paulo, Brazil
UNORTE - University Center of Northern São Paulo, Dentistry department, São José do Rio Preto, São Paulo, Brazil
UNORTE - University Center of Northern São Paulo, Dentistry department, São José do Rio Preto, São Paulo, Brazil
UNORTE - University Center of Northern São Paulo, Dentistry department, São José do Rio Preto, São Paulo, Brazil / UNIPOS - Post graduate and continuing education, Dentistry department, São José do Rio Preto, São Paulo, Brazil
UNORTE - University Center of Northern São Paulo, Dentistry department, São José do Rio Preto, São Paulo, Brazil / UNIPOS - Post graduate and continuing education, Dentistry department, São José do Rio Preto, São Paulo, Brazil
Aneurysmal bone cyst Tumors Incidence Treatments Maxillofacial

Abstract

Introduction: Aneurysmal bone cysts (ABC) are pseudocysts expansive lesions. The World Health Organization (WHO) categorizes primary ABCs as cystic neoplasms that contain fibrous septa separating numerous blood-filled spaces. Approximately 70% of ABC cases are primary, while 30% are secondary. Objective: The present study aimed to carry out a concise systematic review of the main clinical findings of aneurysmal bone cysts, highlighting the incidence and prevalence, as well as the main forms of treatment. Methods: The rules of the Systematic Review-PRISMA Platform were followed. The research was carried out from May 2022 to July 2022 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results: A total of 143 articles were found. In total, 73 articles were evaluated and 10 were included and evaluated in the systematic review. The symmetric funnel plot does not suggest a risk of bias. After prospecting the main literary findings, it was generally evidenced that the aneurysmal bone cyst (ABC) is a rare lesion that is more frequently found in young adults and children. It may have unpredictable behavior, with a high recurrence rate after treatment. Standard treatment consists of curettage plus local adjuvants and bone grafting to fill the void. In anatomic sites with difficult surgical access, percutaneous procedures are used (injection of sclerosing agents, radiofrequency thermal ablation, or selective arterial embolization. Medical management with bisphosphonates or denosumab has also been advocated. Conclusion: Primary ABCs involving the maxillofacial region are extremely rare and even more in patients with advanced age. Next-generation sequencing confirmed the presence of a USP6-CDH11 fusion gene, consistent with classification as a primary aneurysmal bone cyst. Sclerotherapy provided an effective and minimally invasive treatment for aneurysmal bone cysts and is particularly useful for deep injuries, challenging surgical access, and potentially injurious vital structures.

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References

  1. Jaffe HL, Lichtenstein L. Solitary unicameral bone cyst: with emphasis on the roentgen picture, the pathologic appearance and the pathogenesis. Arch Surgery 1942; 44: 1004–10025.
  2. Jordan RC, Koutlas I, Raubenheimer EJ. et alAneurysmal bone cyst. In: El- NaggarAK, JohnKCC, GrandisJR, et al., eds. WHO Classification of Head and Neck Tumours. 4th ed. Lyon: IARC; 2017, pp. 258–59.
  3. Rajasekaran S, Aiyer SN, Shetty AP, Kanna R, Maheswaran A. Aneurysmal bone cyst of C2 treated with novel anterior reconstruction and stabilization. Eur Spine J. 2019 Feb;28(2):270-278. doi: 10.1007/s00586-016-4518-0. Epub 2016 Mar 23. PMID: 27007865.
  4. Oliveira AM, Perez- Atayde AR, Inwards CY, Medeiros F, Derr V, Hsi B- L, et al. USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so- called secondary aneurysmal bone cysts. Am J Pathol 2004; 165: 1773–80. https://doi.org/10.1016/S0002-9440(10)63432-3
  5. Hiemcke-Jiwa LS, van Gorp JM, Fisher C, Creytens D, van Diest PJ, Flucke U. USP6- associated neoplasms: A rapidly expanding family of lesions. Int J Surg Pathol 2020; 28: 816–25. https://doi.org/10.1177/1066896920938878
  6. Richardson J, Litman E, Stanbouly D, Lee KC, Philipone E. Aneurysmal bone cyst of the head & neck: A review of reported cases in the literature. J Stomatol Oral Maxillofac Surg 2022; 123: 59–63. https://doi.org/10.1016/j.jormas.2021.01.014
  7. Applebaum D, Calo O, Neville K. Implementation of quiet time for noise reduction on a medical- surgical unit. J Nurs Adm 2016; 46: 669–74. https://doi.org/10.1097/NNA.0000000000000424
  8. Motamedi MHK, Navi F, Eshkevari PS, Jafari SM, Shams MG, Taheri M, et al. Variable presentations of aneurysmal bone cysts of the jaws: 51 cases treated during a 30- year period. J Oral Maxillofac Surg 2008; 66: 2098–2103. https://doi.org/10.1016/j. joms.2008.05.364.
  9. Brooks PJ, Chadwick JW, Caminiti M, Dickson B, Leong I. Primary aneurysmal bone cyst of the mandibular condyle with USP6-CDH11 fusion. Pathol Res Pract. 2019 Mar;215(3):607-610. doi: 10.1016/j.prp.2018.10.038. Epub 2018 Nov 2. PMID: 30401581.
  10. Sun Z- J, Zhao Y- F, Yang R- L, Zwahlen RA. Aneurysmal bone cysts of the jaws: analysis of 17 cases. J Oral Maxillofac Surg 2010; 68: 2122–28. https://doi.org/10.1016/j.joms.2009.07.111.
  11. Smith AJ, Choby G, Van Gompel JJ, Link MJ, Van Abel KM. Aneurysmal bone cysts of the paranasal sinuses. The Mayo Clinic Experience and Review of the Literature Laryngoscope 2021; 131: 2525–33.
  12. Cottalorda J, Bourelle S. Modern concepts of primary aneu-rysmal bone cyst. Arch Orthop Trauma Surg 2007; 127: 105–14. https://doi.org/10.1007/s00402-0060223-5.
  13. Mahnken AH, Nolte- Ernsting CCA, Wildberger JE, Heussen N, Adam G, Wirtz DC, et al. Aneurysmal bone cyst: value of MR imaging and conventional radiography. Eur Radiol 2003; 13: 1118–24. https://doi.org/10.1007/s00330-002-1668-8.
  14. Fennessy BG, Vargas SO, Silvera MV, Ohlms LA, McGill TJ, Healy GB, et al. Paediatric aneurysmal bone cysts of the head and neck. J Laryngol Otol 2009; 123: 635–41. https://doi.org/10. 1017/S002221510800337X.
  15. Senol U, Karaali K, Akyüz M, Gelen T, Tuncer R, Lüleci E. Aneu-rysmal bone cyst of the orbit. AJNR Am J Neuroradiol 2002; 23: 319–21.
  16. Asaumi J, Konouchi H, Hisatomi M, Matsuzaki H, Shigehara H, Honda Y, et al. MR features of aneurysmal bone cyst of the mandible and characteristics distinguishing it from other lesions. Eur J Radiol 2003; 45: 108–12. https://doi.org/10.1016/s0720- 048x(02)00008-6.
  17. Segall L, Cohen- Kerem R, Ngan BY, Forte V. Aneurysmal bone cysts of the head and neck in pediatric patients: A case series. Int J Pediatr Otorhinolaryngol 2008; 72: 977–83.
  18. Muratori F, Mondanelli N, Rizzo AR, Beltrami G, Giannotti S, Capanna R, Campanacci DA. Aneurysmal Bone Cyst: A Review of Management. Surg Technol Int. 2019 Nov 10;35:325-335. PMID: 31476792.
  19. Smit C, Robinson L, Roman Tager E, Roza ALOC, Rocha AC, Santos-Silva AR, Vargas PA, Romañach MJ, Fonseca FP, Carlos R, van Heerden WF. Clinicoradiological spectrum of primary aneurysmal bone cysts of the maxillofacial region: A series of 31 cases. Dentomaxillofac Radiol. 2022 Jul 1;51(5):20220071. doi: 10.1259/dmfr.20220071. Epub 2022 May 23. PMID: 35522705.
  20. Rau LH, Reinheimer A, Meurer MI, Marodin AL, Espezim CS, Klüppel LE, Dos Santos Vaz Fernandes PC, Rivero ERC. Fibrous dysplasia with secondary aneurysmal bone cyst-a rare case report and literature review. Oral Maxillofac Surg. 2019 Mar;23(1):101107. doi: 10.1007/s10006-019-00741-w. Epub 2019 Feb 13. PMID: 30758737.
  21. Yeom HG, Yoon JH. Concomitant cemento-osseous dysplasia and aneurysmal bone cyst of the mandible: a rare case report with literature review. BMC Oral Health. 2020 Oct 9;20(1):276. doi: 10.1186/s12903-020-01264-7. PMID: 33036586; PMCID: PMC7547449.
  22. Rațiu C, Ilea A, Gal FA, Ruxanda F, Boşca BA, Miclăuș V. Mandibular aneurysmal bone cyst in an elderly patient: Case report. Gerodontology. 2018 Jun;35(2):143-146. doi: 10.1111/ger.12325. PMID: 29733532.
  23. Brooks PJ, Chadwick JW, Caminiti M, Dickson B, Leong I. Primary aneurysmal bone cyst of the mandibular condyle with USP6-CDH11 fusion. Pathol Res Pract. 2019 Mar;215(3):607-610. doi: 10.1016/j.prp.2018.10.038. Epub 2018 Nov 2. PMID: 30401581.
  24. Al-Maghrabi H, Verne S, Al-Maghrabi B, Almutawa O, Al-Maghrabi J. Atypical Presentation of Giant Mandibular Aneurysmal Bone Cyst with Cemento-Ossifying Fibroma Mimicking Sarcoma. Case Rep Otolaryngol. 2019 Aug 27;2019:1493702. doi: 10.1155/2019/1493702. PMID: 31534810; PMCID: PMC6732594.
  25. Álvarez-Martínez EC, Posso-Zapata MV, Flórez-Arango VA, Lopera-Valle JS, Ardila CM. Aneurysmal bone cyst of the mandible with conservative surgical management: A case report. J Clin Exp Dent. 2019 Jun 1;11(6):e561-e564. doi: 10.4317/jced.55771. PMID: 31346378; PMCID: PMC6645265.
  26. Kumar D, Kumar S, Kumar D, Patel BM, Kumar A, Kumar S, Waliullah S. Sclerotherapy for Aneurysmal Bone Cyst: A Single-Center Experience. Cureus. 2021 Oct 4;13(10):e18469. doi: 10.7759/cureus.18469. PMID: 34754635; PMCID: PMC8564749.
  27. Rehman R, Dekhou A, Osto M, Agemy J, Chaaban A, Yuhan B, Thorpe E. Aneurysmal Bone Cysts of the Craniofacial Origin: A Systematic Review. OTO Open. 2021 Oct 24;5(4):2473974X211052950. doi: 10.1177/2473974X211052950. PMID: 34723050; PMCID: PMC8549472.

How to Cite

Vasconcelos, A. de P., Bannak, I. B. P. E., Naves, I. R. G. D., Azevedo, R. G., & Tessarin, G. W. L. (2022). Incidence and major clinical approaches of aneurismatic bone cysts: a concise systematic review. MedNEXT Journal of Medical and Health Sciences, 3(S6). https://doi.org/10.54448/mdnt22S603