Skip to main content Skip to main navigation menu Skip to site footer
Case Report
Published: 05-13-2022

Case report on the localized cutaneous leishmaniasis: intralesional treatment with meglumine antimoniate

UNIFEV - University Center of Votuporanga-SP- Medical Course, Brazil
UNIFEV - University Center of Votuporanga-SP- Medical Course, Brazil
UNIFEV - University Center of Votuporanga-SP- Medical Course, Brazil
UNIFEV - University Center of Votuporanga-SP- Medical Course, Brazil
UNIFEV - University Center of Votuporanga-SP- Medical Course, Brazil
UNIFEV - University Center of Votuporanga-SP- Medical Course, Brazil
UNIFEV - University Center of Votuporanga-SP- Medical Course, Brazil
UNIFEV - University Center of Votuporanga-SP- Medical Course, Brazil
Tegumentary Leishmaniasis Bauru ulcer Leishmania braziliensis Treatment Meglumine antimoniate

Abstract

Introduction: Leishmaniasis is a contagious disease endemic in Brazil, transmitted by a vector, and its installation and form of presentation depend on the immunological status, location, and type of transmitted protozoan. Objective: A case report of a patient with localized American tegumentary leishmaniasis. Method: Reviews of medical records, analysis of photographic records of diagnostic tests and the evolution of the treatment to which the patient was submitted and literature review were carried out. Case Report: An 85-year-old woman, with a history of a single lesion on the 4 cm right forearm, with raised borders, ulcerated and clean bottom, subcutaneous edema, local pain and heat, pruritus, bloody secretion in small amounts, and no systemic symptoms. The same did not show improvement with the use of ointments (dexamethasone, neomycin, ketoconazole) and lasted for 2 months. The diagnosis of leishmaniasis was confirmed and treatment with intralesional meglumine antimoniate was carried out, with the application of 3 injections with an interval of 15 days. Final considerations: The case reported and the studies surveyed reveal the importance of the new treatment route and show that, although the approach requires specific conditions, such as being a single lesion, it courses with fewer adverse effects, lower cost, and greater safety.

Metrics

Metrics Loading ...

References

  1. Ursine RL, Rocha MF, Sousa JF, Santos RCD, Soares MD, Gusmão MSF, Leite ME, Vieira TM. American Tegumentary Leishmaniasis in an endemic municipality in the North of Minas Gerais State: spatial analysis and socio-environmental factors. Rev Inst Med Trop Sao Paulo. 2021 Jan 20;63:e2. doi: 10.1590/S1678-9946202163002. PMID: 33503150; PMCID: PMC7816867.
  2. Carvalho SH, Frézard F, Pereira NP, Moura AS, Ramos LMQC, Carvalho GB, Rocha MOC. American tegumentary leishmaniasis in Brazil: a critical review of the current therapeutic approach with systemic meglumine antimoniate and short-term possibilities for an alternative treatment. Trop Med Int Health. 2019 Apr;24(4):380-391. doi: 10.1111/tmi.13210. Epub 2019 Feb 19. PMID: 30681239.
  3. Galvão EL, Rabello A, Cota GF. Efficacy of azole therapy for tegumentary leishmaniasis: A systematic review and meta-analysis. PLoS One. 2017 Oct 9;12(10):e0186117. doi: 10.1371/journal.pone.0186117. PMID: 29016694; PMCID: PMC5633178.
  4. Veronesi R, Focaccia R. Tratado de Infectologia: 5. ed. São Paulo: Atheneu, 2015.
  5. BRASIL. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Manual de vigilância da leishmaniose tegumentar / Ministério da Saúde, Secretaria de Vigilância em Saúde, Departamento de Vigilância das Doenças Transmissíveis. – Brasília : Ministério da Saúde, 2017.
  6. World Health Organization (WHO). Control of the leishmaniasis: report of a meeting of the WHO Expert Committee on the Control of Leishmaniases. Geneva: World Health Organ Tech Rep Ser 949; 2010. p. 1-186.
  7. Sinan SN. Leishmaniose tegumentar americana - Casos confirmados Notificados no Sistema de Informação de Agravos de Notificação - Brasil. Available in: <http://tabnet.datasus.gov.br/cgi/tabcgi.exe?sinannet/cnv/ltabr.def>. Accessed in: Juny,29,2018.
  8. Veronesi R, Focaccia R. Tratado de Infectologia: 4. ed. São Paulo: Atheneu, 1997.
  9. OPS-Organización Panamericana de la Salud. Leishmaniasis en las Américas: Recomendaciones para el tratamiento. Washington: OPS; 2013. p. 1-60.
  10. MINISTÉRIO DA SAÚDE; FUNDAÇÃO NACIONAL DE SAÚDE. Manual de Controle da Leishmaniose Tegumentar Americana, Brasília, 2010.
  11. Arboleda M et al. Successful treatment of cutaneous leishmaniasis with intralesional meglumine antimoniate: A case series. Rev. Soc. Bras. Med. Trop., Uberaba , v. 52, e20180211, 2019. Available from <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100713&lng=en&nrm=iso>.access on 08 July 2019. Epub May 16, 2019. http://dx.doi.org/10.1590/0037-8682-0211-2018.
  12. Duque MCO et al. Standardization of intralesional meglumine antimoniate treatment for cutaneous leishmaniasis. Rev. Soc. Bras. Med. Trop., Uberaba, v. 49, n. 6, p. 774-776, Dec. 2016. Available from <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822016000600774&lng=en&nrm=iso>.access on 26 Aug. 2019. http://dx.doi.org/10.1590/0037-8682-0213-2016.
  13. WORLD HEALTH ORGANIZATION (WHO). Control of the Leishmaniases. WHO Technical Report Series No.: 949. Geneva: World Health Organization; 2010. 186p.
  14. Vasconcellos ECF. Tratamento intralesional da leishmaniose cutânea com antimoniato de meglumina no Instituto de Pesquisa Clínica Evandro Chagas, Fiocruz, Rio de Janeiro (2002 a julho 2011). 2013. 92f. Tese (Doutorado em Pesquisa Clínica em Doenças Infecciosas) - Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, RJ, 2013.
  15. BRASIL. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Manual de vigilância da leishmaniose tegumentar / Ministério da Saúde, Secretaria de Vigilância em Saúde, Departamento de Vigilância das Doenças Transmissíveis. – Brasília : Ministério da Saúde, 2017.
  16. MINISTÉRIO DA SAÚDE; FUNDAÇÃO NACIONAL DE SAÚDE. Manual de Controle da Leishmaniose Tegumentar Americana, Brasília, 2010.

How to Cite

Lourencini, Y. G., Siqueira, M. P. de, Maekawa, M. F., Mazzoni, L. B., Almeida, A. M. V. de, D’Amico, P. C., Pereira, L. H. S., & Oliveira, T. T. de. (2022). Case report on the localized cutaneous leishmaniasis: intralesional treatment with meglumine antimoniate. MedNEXT Journal of Medical and Health Sciences, 3(3). https://doi.org/10.54448/mdnt22302